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Human receptors for sweet and umami taste
The three members of the T1R class of taste-specific G protein-coupled receptors have been hypothesized to function in combination as heterodimeric sweet taste receptors. Here we show that humanExpand
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T2Rs Function as Bitter Taste Receptors
Bitter taste perception provides animals with critical protection against ingestion of poisonous compounds. In the accompanying paper, we report the characterization of a large family of putativeExpand
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A Novel Family of Mammalian Taste Receptors
In mammals, taste perception is a major mode of sensory input. We have identified a novel family of 40-80 human and rodent G protein-coupled receptors expressed in subsets of taste receptor cells ofExpand
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Different functional roles of T1R subunits in the heteromeric taste receptors.
The T1R receptors, a family of taste-specific class C G protein-coupled receptors, mediate mammalian sweet and umami tastes. The structure-function relationships of T1R receptors remain largelyExpand
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Putative Mammalian Taste Receptors A Class of Taste-Specific GPCRs with Distinct Topographic Selectivity
Taste represents a major form of sensory input in the animal kingdom. In mammals, taste perception begins with the recognition of tastant molecules by unknown membrane receptors localized on theExpand
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T1r-taste receptors and their coding genes
An isolated nucleic acid selected from the group consisting of: (I) a genomic DNA sequence which essentially consists of a nucleic acid sequence encoding for an active in the flavor display GExpand