• Publications
  • Influence
An update on the biology and physiology of resistin
  • E. Adeghate
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 1 October 2004
TLDR
Evidence of a direct link between resistin genotype and human diabetes is still weak, and more molecular, physiological and clinical studies are needed to determine the role of resistin in the aetiology of type 2 diabetes. Expand
Distribution of vasoactive intestinal polypeptide, neuropeptide-Y and substance P and their effects on insulin secretion from the in vitro pancreas of normal and diabetic rats☆
TLDR
It is shown that VIP and NPY can stimulate insulin secretion from the pancreas after the onset of diabetes and the stimulatory effect of SP on insulin secretion is reversed to inhibitory in diabetic rats. Expand
Increase in neuronal nitric oxide synthase content of the gastroduodenal tract of diabetic rats
Abstract: This study examined the changes occurring in the pattern of distribution and expression of neuronal nitric oxide synthase (nNOS)-positive nerves in the gastroduodenal tract ofExpand
Diabetes Mellitus – Multifactorial in Aetiology and Global in Prevalence
  • E. Adeghate
  • Medicine
  • Archives of physiology and biochemistry
  • 1 January 2001
TLDR
Diabetes mellitus is one of the most common endocrine disorders affecting almost 6% of the world’s population and the prevalence of this chronic metabolic disease is on the increase. Expand
Orexin-1 Receptor Co-Localizes with Pancreatic Hormones in Islet Cells and Modulates the Outcome of Streptozotocin-Induced Diabetes Mellitus
TLDR
The tissue level of OX1R protein increased with the duration of DM especially in type 1 diabetes where it co-localized with cleaved caspase 3 in islet cells, and the findings suggest an important role for the OX-OX1R pathway in STZ-induced experimental diabetes. Expand
Immunohistochemical identification of pancreatic hormones, neuropeptides and cytoskeletal proteins in pancreas of the camel (Camelus dromedarius)
  • E. Adeghate
  • Biology, Medicine
  • Journal of morphology
  • 1 February 1997
TLDR
It is concluded that INS, GLU, ANP, NPY, CCK‐8, NF, S‐100, and VIM are well distributed in the pancreas of the camel. Expand
Immunohistochemical identification and effects of atrial natriuretic peptide, pancreastatin, leucine-enkephalin, and galanin in the porcine pancreas
TLDR
The results of the study have demonstrated a close association of peptidergic fibers with the secretory cells of the pancreas, which can release peptides that in turn can stimulate protein and amylase secretion. Expand
Morphometric and immunohistochemical study on the endocrine cells of pancreatic transplants.
The endocrine cells of embryonic pancreatic tissue fragments transplanted into the anterior eye-chamber of rats for 74 days were investigated immunohistochemically and morphometrically and theExpand
Immunohistochemical localization of orexin-B, orexin-1 receptor, ghrelin, GHS-R in the lacrimal gland of normal and diabetic rats
TLDR
Orexin-B, ghrelin and their receptors are present in the Lacrimal glands of both normal and diabetic rats and may play a role in the regulation of lacrimal gland function. Expand
Epidemiology of diabetes mellitus – a global and regional perspective
TLDR
Reports show that the prevalence of DM is high in Gulf Cooperation Council countries compared with other regions of the world, except for the Pacific islands, and a concerted effort is needed to combat the increasing prevalence. Expand
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