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A unique serine-rich repeat protein (Srr-2) and novel surface antigen (epsilon) associated with a virulent lineage of serotype III Streptococcus agalactiae.
Results indicate that the RDP III-3/ST-17 lineage expresses Srr-2 and is highly virulent in an in vivo model of neonatal sepsis. Expand
Respiratory Viruses Augment the Adhesion of Bacterial Pathogens to Respiratory Epithelium in a Viral Species- and Cell Type-Dependent Manner
The distinct responses of different cell types to viral infection are highlighted and the need to consider this variation when interpreting studies of the interactions between respiratory cells and viral pathogens is considered. Expand
Nontypeable Haemophilus influenzae Adheres to Intercellular Adhesion Molecule 1 (ICAM-1) on Respiratory Epithelial Cells and Upregulates ICAM-1 Expression
It is reported that NTHI interacts with intracellular adhesion molecule 1 (ICAM-1) expressed by respiratory epithelial cells, and upregulates the expression of its own receptor in order to reduce respiratory colonization by N THI and limit the frequency and severity of NTHi infection. Expand
Phylogenetic Lineages of Invasive and Colonizing Strains of Serotype III Group B Streptococci from Neonates: a Multicenter Prospective Study
The hypothesis that ST-17 complex GBS are more virulent than other serotype III GBS is supported, and lineages associated with invasive disease are determined. Expand
Identification of a highly encapsulated, genetically related group of invasive type III group B streptococci.
Data indicate that a group of genetically related organisms with increased capsule production causes the majority of invasive type III GBS disease. Expand
Serotype III Streptococcus agalactiae from Bovine Milk and Human Neonatal Infections1
Although largely unrelated, many bovine type III GBS appear to share a common ancestor with an important human clone.
Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b: emerging pathogen in the vaccine era?
The hypothesis that the IS1016-bexA deletion may identify more virulent strains of H influenzae may support the hypothesis that other serotypes might acquire virulence traits and emerge as important pathogens of children. Expand
Nontypeable Haemophilus influenzae and Streptococcus pneumoniae bind respiratory syncytial virus glycoprotein.
It is demonstrated that RSV G protein is a receptor for both NTHi and S. pneumoniae, and strategies to prevent this interaction may reduce the incidence of secondary bacterial complications of RSV infection. Expand
Identification of Clinical Coryneform Bacterial Isolates: Comparison of Biochemical Methods and Sequence Analysis of 16S rRNA and rpoB Genes
The most sensitive tests were the API Coryne system and amplification and sequencing of the 16S rRNA gene using primers optimized for coryneform bacteria, which correctly identified 9 of 12 control isolates to the species level, and all strains with a high-confidence call were correctly identified. Expand
Prevalence and Distribution of Adhesins in Invasive Non-Type b Encapsulated Haemophilus influenzae
Although the specific complement of adhesin genes in non-type b encapsulated H. influenzae varies, most invasive strains express Hap and Hia, suggesting these adhesins may be especially important to the virulence of these organisms. Expand