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Age‐related decline in brain white matter anisotropy measured with spatially corrected echo‐planar diffusion tensor imaging
Echo planar (EP) diffusion tensor imaging (DTI) permits in vivo identification of the orientation and coherence of brain white matter tracts but suffers from field inhomogeneity‐induced geometricExpand
Equivalent disruption of regional white matter microstructure in ageing healthy men and women
Degree of regional white matter coherence correlated with gait, balance, and interhemispheric transfer test scores, and age-related declines in intravoxel coherence was equally strong and strikingly similar in men and women. Expand
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging
A profile analysis of the integrity of white matter microstructure across the supratentorium and in selected focal regions using DTI data collected at high-field strength, with isotropic voxel acquisition and an analysis based on a concurrently-acquired field map to permit accurate quantification of artifact-prone, anterior and inferior brain regions. Expand
Selective age-related degradation of anterior callosal fiber bundles quantified in vivo with fiber tracking.
Results validate this quantitative fiber tracking approach and confirm the selective vulnerability of frontal white matter systems to normal aging, likely substrates of age-related declines in cognitive processes dependent on prefrontal circuitry integrity. Expand
QUantitative Imaging of eXtraction of oxygen and TIssue consumption (QUIXOTIC) using venular‐targeted velocity‐selective spin labeling
The preliminary data presented suggest that QUIXOTIC will be useful for mapping Yv, OEF, and CMRO2, in both clinical and functional MRI settings. Expand
MRI estimates of brain iron concentration in normal aging using quantitative susceptibility mapping
The robustness, practicality, and demonstrated ability of predicting the change in iron deposition in adult aging suggest that regularized QSM algorithms using single-field-strength data are possible alternatives to tissue iron estimation requiring two field strengths. Expand
Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder
Preliminary data suggest that bipolar disorder patients have decreased DLPF NAA/Cr-PCr, which could represent decreased neuronal density or neuronal dysfunction in the D LPF region. Expand
Dysmorphology and microstructural degradation of the corpus callosum: Interaction of age and alcoholism
Despite abstinence from alcohol, the interaction of age and recent alcoholism history exerted a compounded untoward effect on callosal macrostructure and microstructure of the corpus callosum in alcoholics. Expand
Replicability of diffusion tensor imaging measurements of fractional anisotropy and trace in brain
To evaluate within‐scanner and between‐scanner reliability of fractional anisotropy (FA) and trace (sum of the diagonal elements of the diffusion tensor) as measured by diffusion tensor imaging (DTI).
In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism.
These results provide in vivo evidence for disruption of white matter microstructure in alcoholism and suggest that interruption ofwhite matter fiber coherence contributes to disturbance in attention and working memory in chronic alcoholism. Expand