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Jamaican vomiting sickness. Biochemical investigation of two cases.
We identified methylenecyclopropylacetic acid, a known metabolite of hypoglycin A, in the urine of two patients with Jamaican vomiting sickness. Excretion of unusual dicarboxylic acids such asExpand
Identification of ethylmalonic acid in urine of two patients with the vomitting sickness of Jamaica.
Large amounts of ethylmalonic acid have been identified in urines from two patients with the vomitting sickness of Jamaica. The amounts were 178 and 882 mug per mg creatinine which are 70 and 350Expand
Jamaican vomiting sickness: a study of two adult cases.
An acute illness (Jamaican vomiting sickness) which affected two adults after eating unripe ackee fruit was investigated. Analyses of serum and urine samples were performed to compare the patterns ofExpand
Inhibition of gluconeogenesis in isolated rat liver cells by methylenecyclopropylpyruvate (ketohypoglycin).
1. In isolated rat liver cells, hypoglycin is a less effective inhibitor of gluconeogenesis than its transamination product, methylenecyclopropylpyruvate (ketohypoglycin). 2.Expand
γ-Glutamyl transpeptidase of the ackee plant
Abstract The enzyme γ-glutamyl transpeptidase was purified from seeds of immature ackee fruit ( Blighia sapida ; Sapindaceae) by salt fractionation and gel filtration on Biogel P-10 and P-200. TheExpand
β-Galactosidase from Coffea Arabica and its role in fruit ripening
Abstract β-Galactosidase (EC from ripe coffee berries was purified and characterized. The enzyme displayed activity against p -nitrophenyl-β- d -galactopyranoside (PNPG) ( K m 0.33 mM),Expand
Selective inhibition of acyl-CoA dehydrogenases by a metabolite of hypoglycin.
  • E. A. Kean
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 23 January 1976
Extracts of liver mitochondria from donor rats given hypoglycin, the toxic amino acid from the ackee plant (Blighia sapida) showed drastically reduced levels of acyl-CoA dehydrogenase activity withExpand
Inhibitory action of rhein on the reduced nicotinamide adenine dinucleotidedehydrogenase complex of mitochondrial particles and on other dehydrogenases.
  • E. A. Kean
  • Chemistry, Medicine
  • Biochemical pharmacology
  • 1 July 1970
Abstract The compound, 4,5-dihydroxyanthraquinone-2-carboxylic acid (rhein) was found to be an inhibitor of NADH oxidation by the respiratory chain of beef-heart mitochondrial particles. InhibitionExpand
Studies on the respiratory chain-linked nicotinamide adenine dinucleotide dehydrogenase. XXII. Rhein, a competitive inhibitor of the dehydrogenase.
Abstract Rhein (4,5-dihydroxyanthraquinone-2-carboxylic acid) inhibits the mitochondrial oxidation of reduced nicotamide adenine dinucleotide (NADH) but not of succinate. The inhibition isExpand
Rhein: an inhibitor of mitochondrial oxidations.
  • E. A. Kean
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1968
Abstract Rhein, an anthraquinone derived from plants of the genus Cassia, was found to be an inhibitor of electron transport. Test systems included homogenates and mitochondria, both intact andExpand