E Zandarowska

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L-Histidine (L-HIS), but not D-histidine (each 0.5 g/kg, ip), increased histamine (HI) level in both whole brain as well as in particular brain structures of the rat by approximately 50-60% after 2 hr. Four hours after L-HIS the amine content was still substantially elevated. H1-receptor antagonist, mepyramine (5 and 30 mg/kg ip) and H2-receptor antagonist,(More)
Amodiaquine, 10(-5) M, totally inhibited the activity of histamine-methyltransferase (HMT) in the rat brain. Both peripheral (60 mg/kg i.p.) and central (50 and 100 microgram i.vt.) administration of the drug substantially reduced the HMT activity. Amodiaquine given i.p. or i.vt., in various doses, did not change the endogenous histamine (HI) level in the(More)
The i.p. administration of oxotremorine (2 mg/kg) produced a decrease of both formation of 14C-histamine and the activity of specific histamine-synthetizing enzyme--histidine decarboxylase (HD). Oxotremorine had no effect on histamine level in the brain when given alone, but lowered the amine content in L-histidine-treated rats. All of these effects of(More)
The intraperitoneal administration of three antihistaminic drugs of H1 type: mepyramine, diphenyhydramine (each 5 and 30 mg/kg) and danitracen (2 and 10 mg/kg) did not modify histamine level in the rat brain after 2 h. Histamine H2-receptor antagonists: cimetidine (25-250 microgram) and metiamide (100 microgram) given directly into the brain had no(More)
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