E. Yu. Grigor’eva

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Kinetics of DNA synthesis in mitotic cycle of in mouse corneal epithelial cells after γ-irradiation in different S phase points was studied by the method of autoradiography. Normally, S phase of corneal epithelial cells consists of two phases (S1 and S2) separated by an interval without DNA synthesis. Each phase, in turn, includes two subphases with a pause(More)
Kinetics of DNA synthesis throughout the mitotic cycle in mouse corneal epithelial cells after single γ-irradiation of cells (4 Gy) at the end of S phase was studied by the method of radioautography. It was found that single irradiation increased the duration of S phase due to reparation of damage in the cell at the expense of time that normally falls on g1(More)
The kinetics of DNA synthesis in the mitotic cycle of mouse corneal epithelial cells was studied after a single γ-irradiation of cells in a dose of 4 Gy at different S-phase points. Normally, corneal epitheliocyte S phase consists of S1 and S2 phases separated by an interval during which no DNA is synthesized. The duration of each phase was lengthened after(More)
Kinetics of DNA synthesis in mitotic cycle of mouse corneal epithelial cells after single γ-irradiation (4 Gy) at the end of S period was studied by the method of radioautography. Normally, S period of corneal epithelial cells consists of several stages separated by intervals without DNA synthesis. The estimated mean duration of the first (S1) and second(More)
A very important problem tbr neutron capture therapy (NCT) of patients with malignant neoplasms based on the I~ or, q,)7Li reaction (B-NCT) consists in creating organoboron compounds capable of selectively accumulating in the target tumor tissues. The results of calculations indicate that, provided the thermal neutron fluence reaches an upper limit of 1013(More)
Asynthetic scheme for a transport platform for the creation of new diagnostic and therapeutic antitumor drugs that was based on a dendrimer with a core of pentaerythritol tetraglycidyl ether (TGEPE) and dendra with diallylamine was developed. The transport platform was promising for designing targeted antitumor agents for magnetic resonance tomography and(More)
We proposed a new model of supramolecular DNA structure. Similar to the previously developed by us model of primary DNA structure [11-15], 3D structure of DNA molecule is assembled in accordance to a mathematic rule known as Fibonacci sequence. Unlike primary DNA structure, supramolecular 3D structure is assembled from complex moieties including a regular(More)
Using the autoradiographic method we studied the kinetics of DNA synthesis during themitotic cycle of mouse corneal epithelial cells after γ-irradiation in a dose of 2 Gy at different S-phase points. Normally, S phase in corneal epitheliocytes includes S1 and S2 phases separated by an interval during which DNA is not synthesized. Double exposure modifi es(More)
Binary radiotherapy (BRT) is a type of radiation therapy that employs special drugs to direct ionizing radiation to a target. As a rule, the drug has no significant biological activity of its own. BRT causes damage due to interaction of secondary ionizing radiation with biological tissues. The special drug that accumulates selectively in a tumor contains(More)
Using the autoradiographic method, we studied the kinetics of DNA synthesis over the mitotic cycle in mouse corneal epithelium cells in delayed periods after γ-irradiation in different points of the S phase of the first mitotic cycle. The index labeled cells during 1-3 periods of DNA synthesis most adequately reflects quantitative changes in the cell(More)