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- Publications
- Influence
Activation of c-K-ras is frequent in pancreatic carcinomas of Syrian hamsters, but is absent in pancreatic tumors of rats.
- H. V. van Kranen, E. Vermeulen, +5 authors E. Scherer
- Biology, Medicine
- Carcinogenesis
- 1 August 1991
We have investigated the presence of mutations in ras genes at codons 12, 13 and 61 in chemically induced pancreatic tumors of rats and Syrian hamsters. Mutations were detected by means of… Expand
Immunocytochemical analysis of DNA adducts in single cells: a new tool for experimental carcinogenesis, chemotherapy and molecular epidemiology.
- E. Scherer, J. van Benthem, P. Terheggen, E. Vermeulen, H. Winterwerp, L. den Engelse
- Biology, Medicine
- IARC scientific publications
- 1988
The immunocytochemical staining of carcinogen-DNA adducts by a double peroxidase-anti-peroxidase (PAP) method is critically described. It is a powerful new tool for the investigation of the initial… Expand
Immunocytochemical analysis of O6-alkylguanine shows tissue specific formation in and removal from esophageal and liver DNA in rats treated with methylbenzylnitrosamine, dimethylnitrosamine,…
- E. Scherer, T. van den Berg, E. Vermeulen, H. Winterwerp, L. den Engelse
- Chemistry, Medicine
- Cancer letters
- 1 July 1989
The formation and repair of carcinogen-DNA adducts in esophagus and liver of rats treated with a single i.p. dose of methylbenzylnitrosamine (MBN), dimethylnitrosamine (DMN), diethylnitrosamine (DEN)… Expand
Immunocytochemical localization of DNA adducts induced by a single dose of N-nitroso-N-methylbenzylamine in target and non-target tissues of tumor formation in the rat.
- J. van Benthem, C. Wild, E. Vermeulen, L. den Engelse, E. Scherer
- Biology, Medicine
- Carcinogenesis
- 1 October 1991
The formation and short-term persistence of O6-methylguanine (O6-meGua) and 7-methylguanine (7-meGua) in individual cells of various target and non-target tissues for tumor induction in rats were… Expand
Immunocytochemical identification of DNA adducts, O6-methylguanine and 7-methylguanine, in respiratory and other tissues of rat, mouse and Syrian hamster exposed to…
- J. van Benthem, V. Feron, +4 authors E. Scherer
- Biology, Medicine
- Carcinogenesis
- 1 September 1994
The present paper reports about an immunocytochemical inventory of the cell types involved in the metabolic activation of the tobacco-specific nitrosamine… Expand
Accumulation of O6- and 7-methylguanine in DNA of N-nitroso-N-methylbenzylamine-treated rats is restricted to non-target organs for N-nitroso-N-methylbenzylamine-induced carcinogenesis.
- J. van Benthem, E. Vermeulen, H. Winterwerp, C. Wild, E. Scherer, L. den Engelse
- Chemistry, Medicine
- Carcinogenesis
- 1 November 1992
The distribution and accumulation of O6-methylguanine (O6-meGua) and 7-methylguanine (7-meGua) was investigated immunocytochemically in target and non-target tissues of rats injected twice weekly… Expand
Immunocytochemical localization of DNA adducts in rat tissues following treatment with N-nitrosomethylbenzylamine.
- J. van Benthem, C. Wild, E. Vermeulen, H. Winterwerp, L. den Engelse, E. Scherer
- Chemistry, Medicine
- IARC scientific publications
- 1988
Immunocytochemical visualization of O6-methylguanosine (meGua) and 7-meGua shows that DNA methylation by N-nitrosomethylbenzylamine(NMBzA) occurs not only in the target organs for tumour induction by… Expand