E. V. Tokmacheva

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Among 33 mutant stocks of Drosophila melanogaster generated by means of P-insertional mutagenesis in the system with single P element, 4 stocks have been isolated as demonstrating deficient memory in the conditioned courtship suppression paradigm. Localization of the P insertions never coincided with that of previously known mutations affecting memory.
Four lines were selected from a collection of 33 lines prepared by P insertion mutagenesis using a single-copy P-element system; the males of these four lines showed memory defects after acquisition of conditioned reflex suppression of courting. In two lines (P171 and P95), the dynamics of retention of the conditioned reflex in the repeated(More)
One of the most important questions in the genetics of behavior is that of studies of the mechanisms of learning and memory. A convenient system for this is provided by Drosophila melanogaster, in which a whole series of mutations affecting the formation of different types of memory and learning have been obtained. The brain formations involved in these(More)
After the devastation of genetics in our country academician Leon A. Orbeli has provided an opportunity for the elucidation of evolutionary conserved genes in control of the nervous system functioning, resulting behavior and conditioning. The progress in plant, worm, Drosophila and human genome projects and the bio-informatic analysis of genome sequences(More)
After the devastation of genetics in our country, Academician Leon A. Orbeli has provided an opportunity for the studies on evolutionary conservatism of genes controlling the main properties of the higher nervous activity and conditioning. For the last few years, determination and bioinformatic analysis of genome sequences in the plant, worm, Drosophila,(More)
Drosophila proved to be a very convenient model for genetic dissection of learning and memory in a number of experimental paradigms. A battery of mutations affecting either different subdomains of the central complex (CC) or of the mushroom bodies (MBs) enable the elucidation of the role of these central brain structures in different forms of learning and(More)
The structures and functions of many genes are homologous in Drosophila and humans. Therefore, studying pathological processes in Drosophila, in particular neurogenerative processes accompanied by progressive memory loss, helps to understand the ethiology of corresponding human disorders and to develop therapeutic strategies. It is believed that the(More)
The mitotic activity of cells of the head neural ganglion ofDrosophila larvae of two genetic lines, the agts 3-mutant line, which possesses increased calmodulin activational properties and altered capacity for learning, and the wild type CS line, serving as a control, was studied. The value of the mitotic index, as a ratio of the number of dividing cells to(More)
The data obtained on homeopathic correction of the Drosophila mutant strains with altered activation properties of calmodulin and increased ability for learning, suggest an important role of Ca ions calmodulin in formation of chromocentral organisation of the nucleus. No significant role of the F ions was revealed.