E. V. Tokmacheva

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One of the most important questions in the genetics of behavior is that of studies of the mechanisms of learning and memory. A convenient system for this is provided by Drosophila melanogaster, in which a whole series of mutations affecting the formation of different types of memory and learning have been obtained. The brain formations involved in these(More)
Four lines were selected from a collection of 33 lines prepared by P insertion mutagenesis using a single-copy P-element system; the males of these four lines showed memory defects after acquisition of conditioned reflex suppression of courting. In two lines (P171 and P95), the dynamics of retention of the conditioned reflex in the repeated(More)
The structures and functions of many genes are homologous in Drosophila and humans. Therefore, studying pathological processes in Drosophila, in particular neurogenerative processes accompanied by progressive memory loss, helps to understand the ethiology of corresponding human disorders and to develop therapeutic strategies. It is believed that the(More)
Among 33 mutant stocks of Drosophila melanogaster generated by means of P-insertional mutagenesis in the system with single P element, 4 stocks have been isolated as demonstrating deficient memory in the conditioned courtship suppression paradigm. Localization of the P insertions never coincided with that of previously known mutations affecting memory.
Drosophila proved to be a very convenient model for genetic dissection of learning and memory in a number of experimental paradigms. A battery of mutations affecting either different subdomains of the central complex (CC) or of the mushroom bodies (MBs) enable the elucidation of the role of these central brain structures in different forms of learning and(More)
—After the devastation of genetics in our country academician Leon A. Orbeli has provided an opporr tunity for the elucidation of evolutionary conserved genes in control of the nervous system functioning, resultt ing behavior and conditioning. The progress in plant, worm, Drosophila and human genome projects and the biooinformatic analysis of genome(More)
Published data and the results of experiments conducted at the Laboratory of Genetics of Higher Nervous Activity, Pavlov Institute of Physiology, on the effect of stress on chromosome structure and function are reviewed briefly. Experiments were performed on inbred rats selected for excitation threshold and mutant Drosophila with altered metabolism of(More)
Mechanisms modifying the structural-functional organization of polytene chromosomes were studied in a Drosophila line in which the activating properties of calmodulin were altered and learning ability was increased, by treating mutants with homeopathic preparations which affect Ca2+ and F- ion metabolism. The results indicated a dominant role for Ca2+ ions(More)
The data obtained on homeopathic correction of the Drosophila mutant strains with altered activation properties of calmodulin and increased ability for learning, suggest an important role of Ca ions calmodulin in formation of chromocentral organisation of the nucleus. No significant role of the F ions was revealed.