E. V. Mandriko

We don’t have enough information about this author to calculate their statistics. If you think this is an error let us know.
Learn More
The Soviet preparation sydnophen is used in medical practice as a drug combining a psychostimulant action with moderate antidepressive activity [5, 6]. Sydnophen has been shown to have a central stimulating action, manifested as facilitation of conditioned reflexes, tactile and audiogenic hyperreflexia, and an activating action on the EEG [4]. Sydnophen(More)
Intravenous bolus injection of sydnophen (0.002-20 micrograms/kg) resulted in decrease or complete abolition of bradycardia induced by electrical stimulation of vagal peripheral end of anesthetized cats. The cholinolytic effects are dose-dependent. The small dose of sydnophen (0.002 micrograms/kg) which wasn't able to cause any alteration of EEG, heart rate(More)
In connection with the expansion of the limits of human adaptation and the prophylaxis of overfatigue during the performance of intensive and prolonged tasks, pharmacological stimulators of the vital activity, including mental stimulators, have been receiving increasingly widespread use [9]. Among the mental stimulators, phenylalkylamines are most used. New(More)
The cholinolytic effect of sydnophen discovered in earlier anesthetized cats was confirmed on unanesthetized fish and frogs: the vagal bradycardia induced by electric stimulation of peripheral vagal end was decreased or even abolished by intravenous injection of sydnophen (0.2-20 mg/kg). The amphetamine (0.2-30 mg/kg) also blocked the vagal bradycardia in(More)
  • 1