E. U. Conrad

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Hypoxia imparts resistance to radiotherapy and chemotherapy and also promotes a variety of changes in tumor biology through inducible promoters. The purpose of this study was to evaluate the use of positron emission tomography (PET) imaging with fluorine-18 fluoromisonidazole (FMISO) in soft tissue sarcomas (STS) as a measure of hypoxia and to compare the(More)
We used a miniature swine femoral neck fracture model to demonstrate the effects of the fracture on blood flow, histologic appearance, MRI signal and the development of posttraumatic osteonecrosis. The fracture was created and internally fixed in the right hip of 11 swine, with the left hip serving as the control. Femoral head blood flow via Laser Doppler(More)
OBJECTIVE To test whether patients with Askin tumor treated with aggressive neoadjuvant chemotherapy have a better clinical outcome. DESIGN Retrospective case series. SETTING Pediatric referral center. PATIENTS All children diagnosed with malignant small-cell tumors of the chest wall (Askin tumor) and treated from 1975 to September 1987 (phase 1, n =(More)
BACKGROUND To improve the prognosis for pediatric patients with metastatic sarcomas, including the Ewing sarcoma family of tumors (ESFT), rhabdomyosarcoma (RMS), and undifferentiated sarcoma (UDS), we tested the feasibility of a brief, intensive regimen of chemotherapy that maximizes dose intensity. PROCEDURE Twenty-four children and adolescents with(More)
Clinical experience with positron emission tomography (PET) scanning of sarcoma, using fluorodeoxyglucose (FDG), has established spatial heterogeneity in the standardized uptake values within the tumor mass as a key prognostic indicator of patient survival. But it may be that a more detailed quantitation of the tumor FDG uptake pattern could provide(More)
More than 50 different forms of craniosynostosis and syndromes with craniosynostosis are reported in the literature (Cohen 1979; Buyse 1990). They include monogenic, chromosomal , teratogenic and sporadic entities. None of the known syndromic conditions have congenital cataract as a feature. We recently observed a 2-month-old female with a severe(More)
In general, the 5-year survival for patients with most types of sarcomas has doubled since the 1970s; improved chemotherapy, surgery, radiographic, and pathologic techniques all have contributed to this accomplishment. The 5-year survival for patients with osteosarcoma, like most sarcomas, is approximately 60% when the disease is treated with appropriate(More)
The management of pain after burn injuries is a clinical challenge magnified in patients with significant comorbidities. Presently, burn pain is treated via a wide variety of modalities, including systemic pharmacotherapy and regional analgesia. Although the latter can provide effective pain control in patients with burn injuries, it is relatively(More)
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