OBJECT Sedation regimens for head-injured patients are quite variable. The short-acting sedative-anesthetic agent propofol is being increasingly used in such patients, yet little is known regarding its safety and efficacy. In this multicenter double-blind trial, a titratable infusion of 2% propofol accompanied by low-dose morphine for analgesia was compared… (More)
In the present experiment we addressed the common clinical finding that subsequent to recovery of function, there is often a lingering chronic dysfunction associated with extensive neocortical injury. We have confirmed this observation in the laboratory setting, and the data is compatible with the theoretical position that brain injury induces a shift in… (More)
A novel complication of the illicit use of cocaine, a spontaneous acute subdural hematoma, is described. This case represents another addition to the growing literature on the negative effects of cocaine on the central nervous system. Photographic documentation of the lesion responsible for the hematoma is presented, along with a discussion of the possible… (More)
From the review of the current literature it is quite evident that some exciting prospects are on the horizon which will help to better explain the development and functioning of the visual system. In addition, the new technology of CNS tissue grafting coupled to other newly emerging technologies (i.e., microsurgical, microinjection, and micromanipulative… (More)
A small penetrating incision made through the sclera, choroid and retina of the adult rat eye creates a unique lesion paradigm. More specifically, by one to two weeks after the incision the wound area stabilizes, leaving a clean inflammation-free degeneration gap or 'die-back zone' (200-300 microns wide) between the cut edges of the intact retina. The… (More)
The occurrence of spontaneous subdural hematoma (SDH) in immune thrombocytopenia (ITP) is rare. We report a spontaneous subacute subdural hematoma in a patient with chronic ITP. The patient presented with headache and a noncontrast head CT scan showed an 11 mm subacute right frontoparietal SDH causing an 8 mm right to left midline shift. The patient… (More)
Ibuprofen improves cerebral blood flow after global cerebral ischemia in dogs.
OBJECT This study was conducted to review the presentation and management of patients with coccidioidomycosis involving the spine. METHODS The authors reviewed 23 cases of spinal coccidioidomycosis treated at their institutions. There were 20 males and three females who ranged in age from 9 to 62 years. Non-Caucasian individuals were disproportionately… (More)