E Sochocka

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During vascular insults in the brain (stroke) the extracellular concentrations of glutamate and K+ increase. It is well acknowledged that the increase in glutamate contributes to the death of neuronal cells at an earlier time than they would have succumbed to energy deprivation as such, but the origin of the released glutamate is not known and cannot easily(More)
Effects of hypoxia, substrate deprivation and simulated ischemia (combined hypoxia and substrate deprivation) on cell survival during the insult itself and during a 24 h 'recovery' period were studied in primary cultures of mouse astrocytes and in cerebral cortical neuronal-astrocytic co-cultures. Cell death was determined by release of the cytosolic high(More)
Hypothermia offers protection from the effects of ischemia in small animals. We have recently shown that similar to small animals, hypothermia may also be protective in an astrocytic model of "simulated ischemia" in cell culture. This study was designed to look at the protective effects of hypothermia in cultures of cerebellar granular (glutamatergic) and(More)
A mild decrease in temperature (2-3 degrees) can result in marked attenuation of ischemic neuronal damage in living animals. We now report the protective effects of hypothermia in an astrocyte with simulated ischemia in cell culture system. Hypothermia when used during ischemia showed significant reduction of damage. Brief episodes of post-ischemic(More)
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