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Long latency brain potentials were evoked by infrared laser stimuli (LEPs) applied to the right forehead in order to activate the thinnest cutaneous A-delta afferents of the upper branch of the trigeminal nerve thus inducing a painful sensation. Ten healthy male subjects participated in 4 identical subsequent sessions, one week apart, receiving 4 blocks of(More)
Somatosensory (SEP), auditory evoked potentials (AEP) and power spectral density of ongoing EEG (PSD) were investigated under different drug conditions: the opioid pentazocine (30 mg), the centrally acting non-narcotic analgesic flupirtine (80 mg) and placebo were administered i.v. in a double-blind cross-over study (intersession interval 7 days) with 20(More)
BACKGROUND Low-dose ketamine has been shown to exert analgesic effects. Whether ketamine-induced pain relief may be quantitated by somatosensory evoked cerebral potentials has not been established. METHODS Thirty healthy volunteers were assigned randomly to one of three groups. Subjects of group 1 (n = 10, control) were given saline as placebo. In groups(More)
Single trial event-related cerebral potentials (ERPs) in response to skin stimuli of various intensities and qualities in man were investigated in respect to their nociceptive information content. Electrical constant current stimuli (20 msec, 2 - 8 mA) and mechanical force controlled stimuli (20 msec, 0.8 - 3.2 N) were applied to the tip of the left middle(More)
BACKGROUND Principal component analysis is a multivariate statistical technique to facilitate the evaluation of complex data dimensions. In this study, principle component analysis was used to reduce the large number of variables from multichannel electroencephalographic recordings to a few components describing changes of spatial brain electric activity(More)
The effects of cooling and topical application of menthol on histamine-induced itch, wheal and flare reactions of the left lower arm were investigated in a threefold cross-over design with 15 healthy male volunteers. Lowering skin temperature by cooling from 32.8 +/- 0.3 degrees C to 29.7 +/- 0.5 degrees C reduced itch intensity from 260 +/- 47 units to 55(More)