Learn More
In a prospective study, antiepileptic drugs were discontinued in 264 children with epilepsy after a mean seizure-free interval of 2.9 years. They were then followed for a mean of 58 months to ascertain whether seizures recurred. Seizures recurred in 95 (36%) of the children. Etiology was a significant predictor of outcome (relative risk [RR] = 1.81). On(More)
This chapter addresses the characteristics and spatial distribution of intracellular potentials, the spread of paroxysmal depolarization shifts (PDSs) through the cortex, the extracellular field potentials in three dimensions, and the concentrations of penicillin in direct contact with elements in the epileptogenic focus. Data are presented that show that(More)
The minimal concentrations of penicillin which induce stable recurrent spikes (20,000 U/ml) and which elicit stable recurrent after-discharges (100,000 U/ml) were determined. A quantitative study of the inter-relationships, variability and changes with time of a number of spike parameters (spike latency, spike amplitude, amplitude of prepositivity, spike(More)
1. The EEGs of ten centenarians were described. 2. In most healthy centenarians, posterior dominant rhythms are within the lower part of the alpha range (average 8.62 c/sec). 3. Although slowing of the posterior dominant rhythm at age 100 is greater than in younger groups, there is no evidence in this study of a progressive decrease in frequency during the(More)
OBJECTIVE To assess the long-term recurrence risks after a first unprovoked seizure in childhood. METHODS In a prospective study, 407 children who presented with a first unprovoked seizure were then followed for a mean of 6.3 years from the time of first seizure. RESULTS One hundred seventy-one children (42%) experienced subsequent seizures. The(More)
In a prospective study, 283 children who presented with a first unprovoked seizure were followed for a mean of 30 months from the time of first seizure. Subsequent seizures were experienced by 101 children (36%). The cumulative risk of seizure recurrence for the entire study group was 26% at 12 months, 36% at 24 months, 40% at 36 months, and 42% at 48(More)
We examined EEG findings from an ongoing study of 347 children with a first unprovoked seizure. EEGs were available in 321 (93%), and 135 (42%) had an abnormal EEG. EEG abnormalities included focal spikes (n = 77), generalized spike and wave discharges (n = 28), slowing (n = 43), and nonspecific abnormalities (n = 7). Abnormal EEGs were more common in(More)