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BACKGROUND Remote, non-invasive and objective tests that can be used to support expert diagnosis for Parkinson's disease (PD) are lacking. METHODS Participants underwent baseline in-clinic assessments, including the Unified Parkinson's Disease Rating Scale (UPDRS), and were provided smartphones with an Android operating system that contained a smartphone(More)
OBJECTIVE Youth use of cigars has increased in the USA. Understanding brand preference among youth could help explain the attraction to cigars, and develop prevention strategies. This study reports on youth characteristics associated with preferences for cigar brands. DESIGN Data are presented on 5006 students in grades 7-12 (ages 12-18 years) in(More)
BACKGROUND Careful characterization of the phenotype and genotype of Huntington disease (HD) can foster better understanding of the condition. METHODS We conducted a cohort study in the United States, Canada, and Australia of members of families affected by HD. We collected demographic and clinical data, conducted the Unified Huntington's Disease Rating(More)
OBJECTIVES To evaluate the safety and tolerability of latrepirdine in Huntington disease (HD) and explore its effects on cognition, behavior, and motor symptoms. DESIGN Double-blind, randomized, placebo-controlled trial. SETTING Multicenter outpatient trial. PARTICIPANTS Ninety-one participants with mild to moderate HD enrolled at 17 US and UK centers(More)
We identified characteristics associated with future publication record and academic rank in a cohort of neurology residents from a single institution. Seventy-six percent of women and 94% of men currently hold academic positions (p = 0.10). Early publications may lay the foundation for future academic investigation as publishing before (p = 0.01) and(More)
OBJECTIVE To estimate the level of funding for neuroscience research from federal and industry sources and to examine the therapeutic advances in the neurosciences over the past decade. METHODS We examined financing for neuroscience research over the past decade from the following principal sponsors of biomedical research: the National Institutes of(More)
As the U.S. population ages, the burden of neurodegenerative disorders, including Alzheimer disease and Parkinson disease, will increase substantially. However, many of these patients and their families currently do not receive neurologic care. For example, a recent study found that over 40% of Medicare beneficiaries with an incident Parkinson disease(More)
BACKGROUND An analysis of NIH funding in 1996 found that the strongest predictor of funding, disability-adjusted life-years (DALYs), explained only 39% of the variance in funding. In 1998, Congress requested that the Institute of Medicine (IOM) evaluate priority-setting criteria for NIH funding; the IOM recommended greater consideration of disease burden.(More)
OBJECTIVE To identify design elements of clinical trials leading to US Food and Drug Administration approval of drugs for neurological diseases with and without orphan indications. METHODS We used publicly available information to identify approvals for drugs for neurological diseases with an orphan indication (n = 19) and compared them with recent(More)
BACKGROUND By permitting remote assessments of patients and research participants, telemedicine has the potential to reshape clinical care and clinical trials for Parkinson disease. While the majority of the motor Unified Parkinson's Disease Rating Scale (UPDRS) items can be conducted visually, rigidity and retropulsion pull testing require hands-on(More)