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- Shalin H Naik, Leïla Perié, +4 authors Ton N Schumacher
- Nature
- 2013

Haematopoietic stem cells (HSCs) and their subsequent progenitors produce blood cells, but the precise nature and kinetics of this production is a contentious issue. In one model, lymphoid and myeloid production branch after the lymphoid-primed multipotent progenitor (LMPP), with both branches subsequently producing dendritic cells. However, this model is… (More)

- Carmen Gerlach, Jeroen W.J. van Heijst, +7 authors Ton N.M. Schumacher
- The Journal of experimental medicine
- 2010

The mechanism by which the immune system produces effector and memory T cells is largely unclear. To allow a large-scale assessment of the development of single naive T cells into different subsets, we have developed a technology that introduces unique genetic tags (barcodes) into naive T cells. By comparing the barcodes present in antigen-specific effector… (More)

- Jeroen W J van Heijst, Carmen Gerlach, +7 authors Ton N M Schumacher
- Science
- 2009

The magnitude of antigen-specific CD8+ T cell responses is not fixed but correlates with the severity of infection. Although by definition T cell response size is the product of both the capacity to recruit naïve T cells (clonal selection) and their subsequent proliferation (clonal expansion), it remains undefined how these two factors regulate… (More)

- Koen Schepers, Erwin Swart, +8 authors Ton N.M. Schumacher
- The Journal of experimental medicine
- 2008

T cells, as well as other cell types, are composed of phenotypically and functionally distinct subsets. However, for many of these populations it is unclear whether they develop from common or separate progenitors. To address such issues, we developed a novel approach, termed cellular barcoding, that allows the dissection of lineage relationships. We… (More)

- Lars T van der Veken, Miriam Coccoris, Erwin Swart, J H Frederik Falkenburg, Ton N Schumacher, Mirjam H M Heemskerk
- Journal of immunology
- 2009

The successful application of T cell-based immunotherapeutic applications depends on the availability of large numbers of T cells with the desired Ag specificity and phenotypic characteristics. Engineering of TCR-transferred T lymphocytes is an attractive strategy to obtain sufficient T cells with an Ag specificity of choice. However, the introduction of… (More)

- Miriam Coccoris, Erwin Swart, +4 authors Ton N M Schumacher
- Journal of immunology
- 2008

To broaden the applicability of adoptive T cell therapy to cancer types for which tumor-specific T cells cannot routinely be isolated, an effort has been made to develop the transfer of tumor-specific TCR genes into autologous T cells as a novel immunotherapeutic approach. Although such TCR-modified T cells have been shown to react to Ag encounter and can… (More)

- Moniek A de Witte, Annelies Jorritsma, +5 authors Ton N M Schumacher
- Journal of immunology
- 2008

Transfer of either allogeneic or genetically modified T cells as a therapy for malignancies can be accompanied by T cell-mediated tissue destruction. The introduction of an efficient "safety switch" can potentially be used to control the survival of adoptively transferred cell populations and as such reduce the risk of severe graft-vs-host disease. In this… (More)

- S. J. Gismondi, E. R. Swart
- Math. Program.
- 2004

- E. R. Swart, S. J. Gismondi, N. R. Swart, C. E. Bell, A. Lee
- ArXiv
- 2016

We present a matching and LP based heuristic algorithm that decides graph non-Hamiltonicity. Each of the n! Hamilton cycles in a complete directed graph on n + 1 vertices corresponds with each of the n! n-permutation matrices P , such that p u,i = 1 if and only if the i th arc in a cycle enters vertex u, starting and ending at vertex n + 1. A graph instance… (More)

- E. R. Swart
- APLQ
- 1985

Linear programming problems play s prominent role in operations research and a common form of problem is as follows: maximize ctz subject to Az ~ b z~e0 where the right hand side vector b represents the maximum resource availability of people, materials, machines or time; the columns of the matrix A indicate how much of each of these resources is needed to… (More)