Thromboxane A2(TxA2) is a potent vasoconstrictor associated with cerebrovascular disease and is thought to be synthesized within tissues of the brain. In order to determine the cellular sources of TxA2 in the central nervous system (CNS), we measured the release of the stable metabolite TxB2 in cultures of mixed or highly enriched populations of brain glia.… (More)
We describe two new beamlines for radiation effects research at the Indiana University Cyclotron Facility. Protons with energies up to 205 MeV are available. One of the beamlines offers momentum selected beams at energies as low as 52 MeV. Beam characteristics such as transmission, energy, energy spread and lateral profile are described and compared to… (More)
The accuracy and utility of the dosimetry system used for radiation effects research with high energy protons at The Indiana University Cyclotron Facility, IUCF, has been confirmed by comparison with an independently calibrated Markus ion chamber, a Shulz water calorimeter and GAFCHROMIC tm films.
Plasma prostacyclin (PGI2) degradation rate was measured in a 39-year-old man with chronic thrombotic thrombocytopenic purpura (TTP). His disease responded to plasma exchange, or plasma infusion alone, given at 3-4 week intervals. Plasmapheresis with albumin replacement had an adverse effect. PGI2 degradation rate was measured by incubation of exogenous… (More)
Beam goes from left to right. Number 1 is a removable stop which turns the beam on and off, #2 is a target ladder with a scintillator for beam alignment and a Cu foil to spread the beam, #3 is the defining collimator and Secondary Emission Monitor (SEM), #4 is a removable Faraday cup used to calibrate the SEM, #5 is the exit window, and #6 is the entrance… (More)