E. P. Gus'kov

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Inactivation of the gene ( Uox ) in primates, which is responsible for the synthesis of theenzyme urikase, has determined new ways of social and intellectual evolution of mammals [1, 2]. Almost simultaneously with this process, a mutation occurred, as a result of which primates lacked the capability of endogenous synthesis of ascorbate. These mutations(More)
A new method for estimating the genotoxicity of the urban environment is proposed. The method is based on the analysis of the lipid peroxidation (LPO) rate in leaves of woody plants. The mutagenicity of the urban environment was estimated using standard test systems, including plant root meristem (kidney beans germinated in water with suspended particles(More)
Separate and combined action of nitrosomethylurea (NMU) and heat shock (HS) on germination of seeds of the inbred line 3629 and derived nuclear and plastome mutant lines, n-chlorina-1 and en-chlorina-5, respectively, were studied. NMU at a concentration of 0.015%, as well as HS (40 degrees C), had no effect on the spontaneous level of chromosome aberrations(More)
Allantoin was shown to affect the activities of enzymes involved in regulation of the so-called reactive-oxygenspecies (ROS)-dependent status of an organism [2]. The results reported in [2] support the hypothesis that intermediates of purine base catabolism are antioxidants [3]. For example, uric acid is a potent antioxidant, and Drosophila strains lacking(More)
The effects of heat shock (HS) (40°C for 1 h) on the level of malondialdehyde (MDA), the terminal product of lipid peroxidation, superoxide dismutase (SOD) activity, catalase activity, and total peroxidase activity (TPA) were studied in root meristems and chloroplasts of several sunflower (Helianthus annuusL.) lines that carried nuclear or plastome(More)
High pressure of oxygen induces chromosomal rearrangements in metaphases of human peripherical blood cells treated in vitro. An increase in the percentage of rearrangements was detected in the third mitosis, due mainly to chromatid breaks. The data of cytogenetical analysis of lymphocytes of human blood treated in vivo at 3 ata for 30 min are presented. A(More)
In most vertebrates, intermediate products of purine degradation play the role of molecular quenchers of free radicals. Many authors regard these products as a specific level of systemic antioxidant protection. Carbon dioxide and ammonia are terminal products of enzymatic degradation of purines (e.g., adenine) in fish and amphibians. It is well known that(More)
The hyperbaric oxygenation (HBO) has been studied for its ability to induce the cell death and different genetic variations in normal and repair defective strains of bacteria (Escherichia coli and Salmonella typhimurium) and of yeast (Saccharomyces cerevisiae) strains with different ploidy. HBO is shown to induce an increase in the mutability of(More)
The influence of increased temperature on the intensity of fission and level of chromosome aberrations (ChA) in root meristeme cells of two lines of sunflower seedlings was studied. Within the first hour of seed germination, the temperature of 40 degrees C reduced proliferation activity of root meristeme cells line 3629 for almost the next 15 h of growth.(More)
Separate and combined action of nitrosomethylurea (NMU) and heat shock (HS) on germination of seeds of the inbred line 3629 and derived nuclear and plastome mutant lines, n-chlorina-1 and en-chlorina-5, respectively, were studied. NMU at a concentration of 0.015%, as well as HS (40°C), had no effect on the spontaneous level of chromosome aberrations in root(More)