Learn More
The medial frontal cortex has been shown to modulate emotional behavior and stress responses, suggesting that the dysfunction of this region may be involved in the pathogenesis of depressive symptoms. The present study was performed to determine whether there was any effect of antidepressant treatment on the metabolite levels in the left medial frontal(More)
OBJECTIVES Val66Met BDNF gene polymorphism is shown to affect the function of mature BDNF and mature BDNF plays an important role in the hippocampal neurogenesis and neuronal survival. METHODS A relationship of Val66Met BDNF gene polymorphism and hippocampal volumes in 33 MDD patients and 40 healthy controls is investigated. Region of interest analysis(More)
AIM Serotonin is known for its importance in the pathophysiology of major depressive disorder. Although the hippocampus is one of the key regions in which neurogenesis occurs, and serotonin plays an important role in neurogenesis, results of studies that investigate effect of the 5-HTTLPR polymorphism on hippocampal volumes in major depressive disorder are(More)
OBJECTIVE To determine the effect of BDNF gene val66met polymorphism on serum BDNF levels in drug-free patients with major depressive disorder (MDD) and healthy subjects, that differ by gender. METHODS Sixty-six drug-free patients (19 males+47 females) with non-psychotic MDD and fifty-six healthy controls (18 males+38 females) were recruited. Three-way(More)
In this paper, we establish the need (based on literature and anecdotal evidence) for an infrastructure for CS1 courses to visually support problem solving from the initial problem statement to the code. Then, we describe how using Unified Modeling Language supported by CASE software (Rational Rose) can be used with carefully prepared course materials(More)
Ege University School of Medicine Department of Psychiatry, Izmir-Turkey, Ege University School of Medicine Department of Radiology, Neuroradiology Department Izmir-Turkey, Hacettepe University School of Medicine, Gene Mapping Laboratory, Pediatric Hematology Unit, Department of Pediatrics, Ege University Center for Brain Research, Izmir-Turkey, Institut de(More)
Brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family, and is widely expressed in the adult mammalian brain. Besides its well known neuroprotective activity after traumatic brain injury the evidences regarding its activity dependent release by the pathophysiology of major depression are rapidly replicating. Considering the(More)
The hippocampus seems to be affected in MDD, and brain-derived neurotrophic factor (BDNF) has positive effects on neurogenesis within the hippocampus. Although there are inconsistencies among study results, a smaller hippocampal volume in depressed patients is thought to be related to the pathophysiology of the disease. We looked at the correlation between(More)
Schizophrenia is referred to as cerebral lateralisation abnormality. In this study the possible relationships among handedness, eye dominance, and crossed and non congruent hand-eye dominance in patients with schizophrenia are investigated. A total of 88 patients with schizophrenia and 118 controls were included in the study.The patient group included 60(More)
INTRODUCTION An evolving literature suggests a volume reduction and a loss of functional integrity of prefrontal cortex in depressed patients. Interhemispheric prefrontal functional integrity is mediated via the anterior portion of the corpus callosum. Until recently interhemispheric fibers connecting prefrontal cortex have not been well defined. In this(More)