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Blood levels of the clotting factor fibrinogen and tissue plasminogen activator inhibitor-1 (PAI-1), a primary inhibitor of fibrinolysis, have been positively linked to risk of coronary heart disease. The authors have reported previously that plasma fibrinogen appears to rise after menopause and to be reduced with use of postmenopausal hormonal therapy.(More)
e22099 Background: Growth in biomarkers as therapeutic targets and as surrogate markers for efficacy presents a need for increasingly sensitive immunoassays to expand biomarker applicability. Improved immunoassays will provide: (1) better evaluation and validation of new drug candidates, (2) better matching of patients to new therapies, (3) accelerated drug(More)
e22068 Background: The Ras/Raf/MEK/ERK and PI3K/PTEN/AKT kinase cascades are critical pathways in malignant transformation, tumor progression and multi-drug resistance (MDR) in human cancers. Expression and genetic studies have contributed much to our understanding of this role, but further clinical investigations at the post-transcriptional level are(More)
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