E. N. Slavnova

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Drug resistance and especially cross-resistance are the most important problems of therapy of prostate cancer. Drug resistance mechanisms, including ligand-dependent (requiring the presence of androgens in the cell) and independent (not requiring androgens) ones, are reviewed. The mechanisms are mainly based on mutations of the androgen receptor (AR) gene,(More)
Cell metabolic reprogramming is one of the cancer hallmarks. Glycolysis activation, along with suppression of oxidative phosphorylation and, to a lower extent, the TCA cycle, occurs in the majority of malignant tumors. A bioinformatics search for the glucose metabolism genes that are differentially expressed in colorectal cancer (CC) was performed using the(More)
A study was made of the cytological criteria of various degrees of radiation pathomorphosis of soft tissue cancers and sarcomas in different dose fractionation regimens and varying time of a preoperative interval. Combinations of the main and additional parenchymatous and stromal cytological signs, reflecting pathomorphosis of I-IV degrees were singled out.(More)
A hundred and twenty-nine cytograms of benign tumors of the breast with different degrees of its dysplasia were morphometrically analyzed, by using a "MECOS-Ts" set for digital microscopy. The informative differentially diagnostic morphometric signs of nuclei were identified in mild, moderate, and severe epithelial dysplasias of the breast. The derived(More)
The techniques of flow cytofluorometry and immune cytochemistry combined with routine cytological analysis were applied to 81 patients with non-Hodgkin's lymphomas to diagnose the malignant lymphomas and to determine their immune phenotypes. The accuracy of proposed techniques combination to diagnose the malignant lymphoma consists 98% and to determine the(More)
The study was undertaken to define the capabilities of cytological assay in the detection of metastatic lymph node lesions. A total of 6794 lymph nodes, including 5206 fine-needle biopsy specimens of and 1588 scrapes and imprints of the lymph nodes taken from the patients operated on at the P. A. Herzen Moscow Oncological Research Institute, were analyzed.(More)
Two systems of cytomorphologic signs, one consisting of 40 signs and the other of 12 signs, have been compiled. The former system has been found not answering the needs of differential diagnosis. The system including 12 cytomorphologic signs carries more qualitative information and is better oriented to the tasks of differential diagnosis; another system of(More)
The article discusses the results of comparative study of traditional smears and three different liquid technologies of making ready of cytological preparations (CytoSpin3, E-Prep Processor BD TriPath) using material from 112 patients with pathological processes of such different localizations as exudative liquids (31), soft tissues (22), lymphatic nodes(More)
The paper presents an algorithm for quantification the degree of receptor expression to steroid hormones by automatic analysis of microscope images of immunocytochemical specimens. During experiments a high correlation between the results of the automatic analysis and visual expert assessment was shown and the possibility to apply the proposed algorithm to(More)