E. N. Slavnova

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Drug resistance and especially cross-resistance are the most important problems of therapy of prostate cancer. Drug resistance mechanisms, including ligand-dependent (requiring the presence of androgens in the cell) and independent (not requiring androgens) ones, are reviewed. The mechanisms are mainly based on mutations of the androgen receptor (AR) gene,(More)
Cell metabolic reprogramming is one of the cancer hallmarks. Glycolysis activation, along with suppression of oxidative phosphorylation and, to a lower extent, the TCA cycle, occurs in the majority of malignant tumors. A bioinformatics search for the glucose metabolism genes that are differentially expressed in colorectal cancer (CC) was performed using the(More)
The article discusses the results of comparative study of traditional smears and three different liquid technologies of making ready of cytological preparations (CytoSpin3, E-Prep Processor BD TriPath) using material from 112 patients with pathological processes of such different localizations as exudative liquids (31), soft tissues (22), lymphatic nodes(More)
  • N. S. Gulyak, N. S. Sergeeva, +5 authors S. K. Dzhubalieva
  • 1995
The proliferative activity of 92 breast carcinomas was studied. Statistically significant correlations between the level of proliferative activity and degree of differentiation of tumor cells and nuclear grade were found. Statistically reliable differences in proliferative activity were revealed in the groups of patients under and over 50 years. These facts(More)
A hundred and twenty-nine cytograms of benign tumors of the breast with different degrees of its dysplasia were morphometrically analyzed, by using a "MECOS-Ts" set for digital microscopy. The informative differentially diagnostic morphometric signs of nuclei were identified in mild, moderate, and severe epithelial dysplasias of the breast. The derived(More)
A study was made of the cytological criteria of various degrees of radiation pathomorphosis of soft tissue cancers and sarcomas in different dose fractionation regimens and varying time of a preoperative interval. Combinations of the main and additional parenchymatous and stromal cytological signs, reflecting pathomorphosis of I-IV degrees were singled out.(More)
Bacterial vaginosis (BV) is a highly prevalent infectious disease causing numerous complications in obstetrics, gynecology, and in the newborns. The necessity of investigating BV is explained by its increasing incidence, including its asymptomatic forms, its probable sexual transmission, and its possible role in the etiology and pathogenesis of diseases of(More)
The techniques of flow cytofluorometry and immune cytochemistry combined with routine cytological analysis were applied to 81 patients with non-Hodgkin's lymphomas to diagnose the malignant lymphomas and to determine their immune phenotypes. The accuracy of proposed techniques combination to diagnose the malignant lymphoma consists 98% and to determine the(More)
The study was undertaken to define the capabilities of cytological assay in the detection of metastatic lymph node lesions. A total of 6794 lymph nodes, including 5206 fine-needle biopsy specimens of and 1588 scrapes and imprints of the lymph nodes taken from the patients operated on at the P. A. Herzen Moscow Oncological Research Institute, were analyzed.(More)