As a starting point for modeling of metabolic networks this paper considers the simple Michaelis-Menten reaction mechanism. After the elimination of diffusional effects a mathematically intractable mass action kinetic model is obtained. The properties of this model are explored via scaling and linearization. The scaling is carried out such that kinetic… (More)
It is suggested that the raw materials and technology exist for basing a major fraction of the U.S. chemical industry on four fermentation products, used in the proper portions: ethanol, isopropanol, n-butanol, and 2,3-butanediol. The primary route for introduction of these materials is dehydration of the alcohols and diols to olefins, which would cause… (More)
The objective of the study presented herein is to describe the dynamic behavior of a single biochemical control loop, a simple system but an important element of metabolic networks. This loop is a self-regulated sequence of reactions that converts an initial substrate (S) into a final product (P). It consists of three basic elements: (1) a regulated… (More)
As a strategy to avoid serious allergic reactions to the antitumor agent asparaginase, this enzyme was entrapped in autologous red blood cells before intravenous injection into monkeys. Additional advantages of this approach are prolonged enzyme half-life and targeting of this agent into the reticuloendothelial system.
In 1987, the Chemical Engineering Department of Manhattan College was featured in the winter issue of Chemical Engineering Education . It was a very different time then: the Resource & Learning Center, a computer center used by undergraduate engineers, was not yet built. The study of chemical engineering at Manhattan College was not as technologically… (More)
A mathematical description of transient mass transfer in a Krogh tissue cylinder, for which a solution in transform space was presented previously, is solved in the time domain. The solution is found in the form of an expansion in terms of the eigenfunctions of a non-self-adjoint differential operator, with the eigenvalues being found by way of a… (More)