E N Gorskova

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Psychological testing of 63 normal subjects and 84 patients with keratocone was carried out separately for men and women aged 18-64 years using 11 scores of a brief multifactorial questionnaire for personality examination (BMQP). Comparison of averaged profiles of examined men and women with keratocone showed features of sensitive and psychasthenic(More)
Analysis of deviations in the distribution of HLA antigens and haplotypes characteristic of each of the three patterns of keratocone revealed a genetic predisposition to the development of a certain pattern of the illness. HLA-B27 antigen in the phenotype and increased incidence of haplotypes A2-B27 and A3-B35 were typical of patients with the progressive(More)
Local immunity was studied in 81 patients (146 eyes) aged 11-49 with keratoconus at different stages of the disease running different course. The concentrations of IgG, IgM, secretory IgA, lysozyme, immune complexes, C3 component of the complement, transferrin, and alpha 1-antitrypsin are increased in tears of patients with keratoconus, reflecting the(More)
Local immunity is analyzed in 81 patients (146 eyes) aged 16-49 years with three clinical patterns of keratocone. During long remission, IgG level was the maximum. In progressive disease, sIgA and transferrin levels were increased. The most pronounced shifts were detected in the patients with acute keratocone: increased concentrations of IgM, C3 and C4(More)
Histotyping of HLA I antigens in 100 patients with keratoconus. Europeoids of the Chelyabinsk district, and of 701 controls (donors listed in the regional register) showed an increased incidence of HLA A28, B12, and B15, a decreased incidence of HLA B8, B13, and complete absence of HLA A11. Estimation of HLA haplotypes in keratoconus showed an increased(More)
Three clinical patterns of keratoconus were distinguished in the course of a long (up to 15 years) follow-up of 162 patients with different stages of the disease: chronic progressive stage, long (more than 5.5 years) remission, and acute stage. Keratoconus progresses for up to 5 years in 82.1% of cases. In 11.4% the disease remains at one stage, more often(More)
Cellular and humoral immunity parameters were studied in patients with keratoconus at different stages, aged 14 to 49 years. The results showed the immune homeostasis to be impaired in patients with local involvement of the cornea. At a total system's level the patients developed shifts in the relative content of T-lymphocytes and their subpopulations,(More)
Analysis of 37 corneal disks removed in perforating keratoplasty for stages II-IV keratocone and of 15 corneal disks (control) from subjects dead from mechanical injuries at the age of 17-35 years was carried out. The expression of CD95 receptors on keratocyte membranes was evaluated by indirect immunofluorescent label using rabbit antibodies. Keratocyte(More)