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BACKGROUND Circulating tumor cells (CTCs) play a crucial role in tumor dissemination and are prognostic in primary and metastatic breast cancer. Peripheral blood (PB) immune cells contribute to an unfavorable microenvironment for CTC survival. This study aimed to correlate CTCs with the PB T-cell immunophenotypes and functions of patients with inflammatory(More)
BACKGROUND Cancer stem cells (CSCs) are epithelial tumor cells that express CD44(+)CD24(-/lo). CSCs can be further divided into those that have aldehyde dehydrogenase (ALDH) activity (Aldefluor(+)) and those that do not. We hypothesized that if CSCs are responsible for tumor dissemination, their presence in bone marrow (BM) would be prognostic in early(More)
In each of 14 patients, two small but comparable psoriatic lesions were infused for 2 weeks with either saline or a saline solution of peptide T (as its analog D-ala1-peptide T amide) at 10(-7) mol/L with Alzet osmotic pumps worn extracorporeally. During infusion, lesions were photographed and scored for clinical features of psoriasis on a 9-point scale.(More)
9094 Background: Oxaliplatin-based chemotherapy (FOLFOX or FOLFIRI), a standard first-line chemotherapy for patients with colorectal cancer (CRC), is not only associated with dose-limiting toxicity, such as cumulative sensory neuropathy, but also with debilitating general symptom burden, such as fatigue, pain, and distress. The lack of effective(More)
505 Background: Disseminated tumor cells (DTC) in the bone marrow (BM) are related to poor prognosis of primary breast cancer (PBC). Cancer-initiating stem cells (CSC) have been detected in BM of PBC patients. Downregulation of the Notch pathway leads to murine mammary stem cell expansion and its expression is an early event in breast cancer. We enumerated(More)
e11061 Background: Sialyl Lewis X (sLeX), a carbohydrate antigen on tumor cells and ligand for E-selectin, mediates tethering and rolling along vascular endothelium. sLeX on tumor cells is purported to correlate with metastasis and poor prognosis. Inflammatory cytokines promote tumorigenesis and modulate metastasis. We assessed serum levels of sLeX and(More)
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