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PURPOSE The present study describes the patterns and predictors of treatment persistence and adherence among patients who are diagnosed with glaucoma or as glaucoma suspects (based on claims codes). DESIGN A retrospective cohort study using health insurance claims data. METHODS Newly treated individuals with diagnosed glaucoma (n = 3623) and suspect(More)
PURPOSE To describe prescription refill patterns of ocular hypotensive therapies and to measure differences among refill rates across bottle sizes. DESIGN Retrospective, population-based, cohort study. METHODS This study included patients dispensed bimatoprost, brimonidine, dorzolamide/timolol, latanoprost, timolol gel (XE) 0.5%, or travoprost between(More)
BACKGROUND Linezolid is a novel oxazolidinone antibiotic that is effective for the treatment of gram-positive bacterial infections. The oral formulation has the potential to reduce length of stay (LOS) when used as a substitute for parenteral glycopeptide antibiotics. In a recent multinational trial comparing linezolid (i.v. followed by oral administration)(More)
In a recent multinational trial, hospital resource use and total cost of treatment were compared between linezolid and teicoplanin for severe Gram-positive bacterial infections among 227 European hospitalised patients. The results show that the linezolid group had a 3.2-day (6.3 for linezolid versus 9.5 for teicoplanin groups) shorter mean intravenous(More)
OBJECTIVE Quantify the incremental health care costs and workplace absence and short-term disability costs, to payers and employers, of patients hospitalized for acute coronary syndrome (ACS). METHODS Retrospective study using medical insurance claims for the years 2002 to 2007. Patients were aged 18 to 64 years and hospitalized for ACS between January 1,(More)
PURPOSE To evaluate persistency of pharmacotherapy in primary open-angle glaucoma suspects (glaucoma suspects) treated with latanoprost and timolol. DESIGN Retrospective, cohort study using the Protocare Sciences managed care database; approximately 3 million members in commercial health maintenance organizations and preferred provider organizations and(More)
BACKGROUND Comparing discontinuation and change rates of glaucoma pharmacotherapies provides insight as to which agents perform more effectively. OBJECTIVE To quantify the rates of discontinuation and change of different glaucoma therapies. METHODS This retrospective, observational study using managed care administrative claims data included patients(More)
OBJECTIVE To examine economic consequences related to rehospitalization following initial acute coronary syndrome (ACS) treatment in United States managed care settings. STUDY DESIGN Retrospective observational studies. RESEARCH DESIGN AND METHODS Retrospective observational studies were conducted on two managed care populations to examine medical(More)
OBJECTIVE To determine the management patterns for glaucoma and suspect glaucoma in a nationally representative sample of newly treated persons. DESIGN Retrospective cohort study of persons enrolled in a large managed care organization. PARTICIPANTS One thousand seven hundred twelve diagnosed suspects and 3623 diagnosed glaucoma patients. METHODS(More)
The same methodologic rigor should be applied in measuring both patient persistency with drug therapy and the natural history of disease: Investigators should design natural history cohort studies and evaluate the resulting data using survival analysis. Although simpler analyses, such as those based on the medication possession ratio, may allow(More)