E M Löberg

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Central sympathetic activation with increased release of noradrenaline occurs during cerebral ischaemia, but it is not certain how the increased sympathetic activity affects neuronal damage. We have studied the effect of dexmedetomidine, a potent alpha 2-adrenergic receptor agonist that reduces the central release of noradrenaline, on neuronal damage after(More)
We studied the effect of tirilazad, an aminosteroid with radical scavenging effect, or its vehicle on cerebral blood flow and neuronal death when given before 15 min of severe global ischemia achieved by hypotensive bilateral carotid clamping in rats. Ischemic blood flows less than 1% of the non-ischemic values were seen in the forebrain regions.(More)
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