E M Khovanova

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The genotoxic activity of four mycotoxins has been studied. A high level of somatic mutagenesis in imaginal disk of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cells cultures was induced only by the strong carcinogen aflatoxin B1. Patulin somewhat elevated the level of somatic mutations in D. melanogaster, but(More)
Ten chemicals were assessed for blastomogenic activity in adult wts/+ heterozygotes of D. melanogaster. All of the strong mammalian carcinogens tested (benzo(a)pyrene (B(a)P), pyrene, aflatoxin B(1), 2-acetylaminofluorene (2-AAF) and cis-dichlorodihydroxydiamminoplatinum IV) were also shown to be strong Drosophila blastomogens. They induced several times(More)
In an experiment with black guinea pigs a phenocopy of vitiligo was obtained by means of the exposure of the skin to the action of p-tert-butyl-phenol (PTBP) or to catechol (C). Two other compounds: 2,2-dihydroxy-diphenylpropane (DDP) and 2, 4, 6-tri-tert-butyl-phenol (TTBP) exerted a hypopigmentary effect. PTBP and C depigmented the skin but caused no(More)
The genotoxic activity of four mycotoxins has been studied. High level of somatic mutagenesis in imaginal discs of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures were inducible only by highly carcinogenic aflatoxin B1. Patulin, a weak direct-action carcinogenic substance, slightly elevated the(More)
A 364 yv strain sensitive to the toxic effect of benzo(a)pyrene (BP) was identified among 49 mutant strains of Drosophila simulans. Heterozygotes female 364 x male Turku obtained by crossing 364 yv species with those of wild BP-resistant Turku strain were more sensitive than female Turku x male 364 heterozygotes to both toxic and mutagenic effects of the(More)
We have identified a Drosophila simulans mutant, 364 yu, that is sensitive to the toxic effects of the procarcinogens B(a)P and 2-AAF. Heterozygotes obtained by crossing it to the wild resistant Turku strain (female 364 yu x male Turku) were more sensitive than heterozygotes obtained from the reciprocal cross (female Turku x male 364 yu) to both the toxic(More)
The basal level of benzo(a)pyrene monooxygenase, epoxide hydrolase and glutathione S-transferase activity as well as the content of cytochrome P-450 were found the same in both compared benzo(a)pyrene (BP) sensitive D. simulans strain 364yv and BP-resistant wild one (Turku). Phenobarbital pretreatment resulted in the same increase level of these enzyme(More)
The regularities of morphogenesis of the ventral wing-hinge structures in the Pth mutants of Drosophila melanogaster were studied using statistical methods. Our views on the vectorial growth of presumptive wing hinge as an entire unity were independently confirmed using statistical methods. The expected duplication forms, the possibility of their(More)
The Pth mutation of Drosophila melanogaster, a unique dominant mutation obtained by us, causes the notum duplications that are followed by the duplications of ventral and dorsal wing-hinge structures. The duplications of the wing hinge have a strictly coordinated structure, can be ranged in a continuous series, and are divided into four distinct types, none(More)