E M Carlisle

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Silicon is required for normal growth and development in the chick when a low silicon diet is fed in a trace element controlled environment. Day-old deutectomized cockerels fed a purified amino acid diet showed significantly retarded growth and development within 2 to 3 weeks. Chicks fed the same diet plus a silicon supplement showed 50 percent higher(More)
Silicon, a relatively unknown trace element in nutritional research, has been uniquely localized in active calcification sites in young bone. Silicon increases directly with calcium at relatively low calcium concentrations and falls below the detection limit at compositions approaching hydroxyapatite. It is suggested that silicon is associated with calcium(More)
Studies were undertaken to determine further effects of silicon deficiency in the chick. The diet and experimental conditions were the same as those used in previous studies to demonstrate the essentiality of silicon for growth and development. Skeletal and other abnormalities involving glycosaminoglycans in formation of articular cartilage and comb(More)
Within the last decade silicon has been recognized as participating in the normal metabolism of higher animals and as being an essential trace element. Silicon is found to perform an important role in connective tissue, especially in bone and cartilage. Bone and cartilage abnormalities are associated with a reduction in matrix components, resulting in the(More)
Studies were undertaken to investigate the effect of feeding a silicon (Si) -deficient diet containing a natural protein in place of the crystalline amino acid-based diets used in earlier studies. Feeding this Si-deficient basal diet with or without supplemental Si to day-old cockerels under trace element-controlled conditions resulted in the production of(More)
This preliminary study was undertaken to investigate the effect of dietary silicon and aluminum on levels of these elements in brain. Two ages of rats, 22 day and 10 month, were assigned to 1 of 4 diets: 1) low silicon; 2) low silicon plus aluminum; 3) silicon supplemented; and 4) silicon supplemented plus aluminum. Rats were 23 and 28 months old upon(More)
Silicon performs an important role in connective tissue, especially in bone and cartilage. Silicon's primary effect in bone and cartilage appears to be on formation of the organic matrix. Bone and cartilage abnormalities are associated with a reduction in matrix components, resulting in the establishment of a requirement for silicon in collagen and(More)
The purpose of this paper was to investigate long bone changes in silicon deficiency more extensively and under a new set of conditions. Long bone abnormalities have been produced in silicon-deficient chicks fed a casein-based rather than amino acid-based diet and under an entirely new set of conditions. As demonstrated previously feeding amino acid diets,(More)