Learn More
Lateral inhibition mediated by Delta/Notch (Dl/N) signaling is used throughout development to limit the number of initially equivalent cells that adopt a particular fate. Although adjacent cells express both Dl ligand and N receptor, signaling between them ultimately occurs in only one direction. Classically, this has been explained entirely by feedback:(More)
Enabled by a dense network of Doppler weather radars with overlapping coverage, Distributed Collaborative Adaptive Sensing (DCAS) represents a new paradigm in remote sensing. Rather than each radar periodically sampling its surroundings with sit-and-spin volume coverage patterns as with today's NEXRAD weather radars, DCAS is an end-user driven approach that(More)
Effector functions and proliferation of T helper (Th) cells are influenced by cytokines in the environment. Th1 cells respond to a synergistic effect of interleukin-12 (IL-12) and interleukin-18 (IL-18) to secrete interferon-gamma (IFN-gamma). In contrast, Th2 cells respond to interleukin-4 (IL-4) to secrete IL-4, interleukin-13 (IL-13), interleukin-5(More)
Genetic analyses in both worm and fly have identified the RhoGAP-like protein Syd-1 as a key positive regulator of presynaptic assembly. In worm, loss of syd-1 can be fully rescued by overexpressing wild-type Liprin-α, suggesting that the primary function of Syd-1 in this process is to recruit Liprin-α. We show that loss of syd-1 from Drosophila R7(More)
Molecular-phylogenetic sequence analyses have provided a new perspective on microbial communities by allowing the detection and identification of constituent microorganisms in the absence of cultivation. In this study we used broad-specificity amplification of ribosomal DNA (rDNA) genes to survey organisms present in the human outer ear canal. Samples were(More)
In vivo, endothelial cells (EC) are constantly exposed to the haemodynamic forces (HF) of pressure, wall shear stress and hoop stress. The main aim of this study was to design, create and validate a novel perfusion bioreactor capable of delivering shear stress and intravascular pressure to EC in vitro and to characterise their morphology, orientation and(More)
The present inability to detect low-flying aircraft over international borders renders governments and citizens vulnerable to problems such as drug trafficking and illegal immigration. This paper describes an approach to comprehensive low-altitude surveillance based on networks of small radars being developed by the NSF Engineering Research Center for(More)
In this paper we present the experience of scaling in parallel a geographic information system modeling framework to hundreds of processors. The project began in an active learning cyberinfrastructure course which was followed by an XSEDE ECSS effort in collaboration across multiple-institutions.
One of the challenges of functional genomics is to create a better understanding of the biological system being studied so that the data produced are leveraged to provide gains for agriculture, human health, and the environment. Functional modeling enables researchers to make sense of these data as it reframes a long list of genes or gene products (mRNA,(More)
IP1 is a prototype CASA radar sensor network located in southwestern Oklahoma whose goal is to detect severe weather in the lower part of the atmosphere. At the center of this system's control loop is its Meteorological Command and Control (MC&C). In this paper, we presented the overall control architecture for the IP1 network and highlight new features(More)