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AIMS/HYPOTHESIS Type 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake. METHODS Eleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 kg/m(2), nine male and two female)(More)
Nanoflagellate protists are algae and protozoa (2– 20 ␮m in size) that play important ecological roles in freshwater and marine microbial communities as primary producers and as consumers of prokaryotic and eukaryotic prey. There is little biogeographical information for most of these minute protists despite their significant role in aquatic food webs. In(More)
OBJECTIVE To determine whether increased daily physical activity improves mitochondrial function and/or lipid oxidation in type 2 diabetes. RESEARCH DESIGN AND METHODS Volunteers with (n = 10) and without (n = 10) type 2 diabetes were matched for habitual physical activity, age, sex, and weight. Basal and maximal mitochondrial activity, physical activity,(More)
The geographical distribution and seasonal abundance of the cosmopolitan heterotrophic flagellate Paraphyso-monas imperforata in several coastal waters was examined using species-specific oligonucleotide hybridization probes which target small subunit ribosomal RNA. P. imperforata was found to occur in several coastal environments , but at very low(More)
Mitochondrial dysfunction has been implicated in the pathogenesis of type 2 diabetes. We hypothesized that any impairment in insulin-stimulated muscle ATP production could merely reflect the lower rates of muscle glucose uptake and glycogen synthesis, rather than cause it. If this is correct, muscle ATP turnover rates in type 2 diabetes could be increased(More)
Mitochondrial dysfunction has been proposed to underlie the insulin resistance of type 2 diabetes. However, the relative time course of insulin action in stimulating ATP turnover rate and glucose uptake in skeletal muscle has not been examined. These two parameters were measured in young healthy subjects using the (31)P MRS saturation transfer method in(More)
In this letter, we propose a parametric modeling technique for the electrocardiogram (ECG) signal based on signal dependent orthogonal transform. The technique involves the mapping of the ECG heartbeats into the singular values (SV) domain using the left singular vectors matrix of the impulse response matrix of the LPC filter. The resulting spectral(More)
CYP450 enzymes are key determinants in drug toxicities, reduced pharmacological effect and adverse drug reactions. Mitragynine, an euphoric compound was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4 and protein expression and resultant enzymatic activity. The mRNA and protein expression of CYP450 isoforms were(More)
Drug metabolism involving cytochrome P450 (CYP) enzymes is a key determinant of significant drug interactions. Deoxyelephantopin was evaluated for its effects on the expression of mRNAs encoding CYP1A2, CYP2D6 and CYP3A4, and protein expression and resultant enzymatic activity. The mRNA and protein expression of cytochrome isoforms were carried out using an(More)