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BACKGROUND This study was designed to evaluate the potential yield of introducing nucleic acid amplification testing (NAT) in blood donation, according to the detection threshold and the pool size. STUDY DESIGN AND METHODS A mathematical model of early HIV-1 population dynamics in blood has been developed and is used to predict the window period for NAT,(More)
A simple stochastic mathematical model is developed and investigated for early human immunodeficiency virus type-1 (HIV-1) population dynamics. The model, which is a multi-dimensional diffusion process, includes activated uninfected CD4(+)T cells, latently and actively infected CD4(+)T cells and free virions occurring in plasma. Stochastic effects are(More)
OBJECTIVE To determine the predictors of virological and clinical failure in patients receiving a protease inhibitor as part of triple therapy. METHODS From the French Hospital Database on HIV, 1402 protease inhibitor-naive patients starting a highly active antiretroviral therapy regimen with ritonavir, saquinavir-hard gel capsule (hgc) or indinavir(More)
In randomized HIV/AIDS clinical trials, CD4 lymphocyte counts and plasma HIV-1 RNA measurements are often used as endpoints. The comparison between treatment groups is mainly based on a summary measure of outcome, so-called summary statistic. Such analyses are often complicated by missing data occurring as drop-outs. For the most currently used summary(More)
Over the last years, mathematical models have been applied in HIV infection to investigate the population dynamics of HIV-1 and cells of the immune system in infected hosts. They have contributed to a better understanding of the pathogenesis of AIDS. Among the model-based works, the quantitative studies carried out by two teams, during the years 1995, 1996(More)
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