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INTRODUCTION Although previous studies have been performed on cartilage explant cultures, the generalized dynamics of cartilage metabolism after extraction from the host are still poorly understood due to differences in the experimental setups across studies, which in turn prevent building a complete picture. METHODS In this study, we investigated the(More)
Previous findings indicated that in-situ chondrocytes die readily following impact loading, but remain essentially unaffected when loaded at the same magnitude but with a slow (non-impact) loading rate. The current study was aimed at identifying the causes for cell death in impact loading by quantifying chondrocyte mechanics when cartilage was compressed(More)
Cartilage lesions change the microenvironment of cells and may accelerate cartilage degradation through catabolic responses in chondrocytes. In this study, we investigated the effects of structural integrity of extracellular matrix (ECM) on chondrocytes by comparing the mechanics of cells surrounded by an intact ECM with cells close to a cartilage lesion(More)
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