Sagvolden Terje1
S. Hobbs1
S. E. Rhodes1
H. Lipp1
C. Thinus-Blanc1
1Sagvolden Terje
1S. Hobbs
1S. E. Rhodes
1H. Lipp
1C. Thinus-Blanc
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The purpose of this study was to determine the effect of the first rat monoclonal antibody (MAb ICR62) to the epidermal growth factor receptor (EGFR) in a phase I clinical trial in patients with unresectable squamous cell carcinomas. This antibody effectively blocks the binding of EGF, transforming growth factor (TGF)-alpha and HB-EGF to the EGFR, inhibits(More)
Eighteen patients with advanced cancer have been treated intravenously with human recombinant tumour necrosis factor (rhTNF). The drug produced febrile reactions at all doses although these were preventable by steroids and indomethacin. Doses at or above 9 x 10(5) units (400 micrograms)m-2 were associated with hypotension, abnormal liver enzymes, leucopenia(More)
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