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This paper discusses the validity of using common random numbers (CRNs) with two-stage selection procedures to improve the possibility of correct selection and discusses the intrinsic subset pre-selection of the <i>Enhanced Two-Stage Selection</i> (ETSS) procedure. We propose using CRNs with <i>Rinott's two-stage selection</i> and ETSS procedures when the(More)
Huntington's disease (HD) is caused by a polyglutamine repeat expansion in the N-terminus of the huntingtin protein. Huntingtin is normally present in the cytoplasm where it may interact with structural and synaptic elements. The mechanism of HD pathogenesis remains unknown but studies indicate a toxic gain-of-function possibly through aberrant protein(More)
IMPORTANCE Cognitive decline is a leading cause of disability and death in old age but its neurobiological bases are not well understood. OBJECTIVE To test the hypothesis that transactive response DNA-binding protein 43 (TDP-43) is related to late-life cognitive decline. DESIGN, SETTING, AND PARTICIPANTS Longitudinal clinical-pathologic cohort study(More)
The present study investigated the neuroanatomical and behavioral effects of human stem cell transplants into the striatum of quinolinic acid (QA)-lesioned rats. Twenty-four rats received unilateral QA (200 nM/microl) injections into the striatum. One week later, rats were transplanted with stem cells derived from human fetal cortex (12 weeks(More)
Neurogenesis occurs continually throughout life in all mammals and the extent of neurogenesis is influenced by many factors including gonadal hormones. Most research regarding hormones and neurogenesis has been performed on non-primate species. To determine whether gonadal hormones can modulate endogenous neurogenesis in the dentate gyrus (DG) of the(More)
3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) use has risen among women of childbearing age. Consequently, there is a substantial risk for fetal exposure from women who are, or become pregnant while abusing MDMA. However, attempts to demonstrate that prenatal MDMA results in neurochemical alterations in rat models have failed. MDMA administration to(More)
A novel population of cells that express typical immature neuronal markers including doublecortin (DCX+) has been recently identified throughout the adult cerebral cortex of relatively large mammals (guinea pig, rabbit, cat, monkey and human). These cells are more common in the associative relative to primary cortical areas and appear to develop into(More)
This paper discusses implementation of a two-stage procedure to determine the simulation run length for selecting the best of <i>k</i> designs. We purpose an <i>Enhanced Two-Stage Selection</i> (ETSS) procedure. The number of additional replications at the second stage for each design is determined by both the variances of the sample means and the(More)
Alzheimer's disease (AD) is often accompanied by extrapyramidal signs attributed to nigrostriatal dysfunction. The association between amyloid deposition and nigrostriatal degeneration is essentially unknown. We showed previously that the striatum and the substantia nigra of transgenic mice harboring familial AD (FAD)-linked APPswe/PS1DeltaE9 mutants(More)