E. J. van den End

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Insect cells (Spodoptera frugiperda) were cultured in a continuous stirred-tank reactor. The effluent was led to a cascade of another two reactors, each containing half the volume of the cell-growth reactor, where the cells were infected with Autographa californica nuclear polyhedrosis virus. For about 10 days production of 107 polyhedra (virus particles(More)
A model, suitable for reactor-design purposes, is presented for the infection process of insect cells with baculovirus in a continuous bioreactor system. The infection process can be described by a first-order reaction mechanism if the viable, non-infected, insect cells are regarded as substrate, and the resulting polyhedra as product. Experimental results(More)
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