E J Hukkanen

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The kinetic parameters of single bonds between neural cell adhesion molecules were determined from atomic force microscope measurements of the forced dissociation of the homophilic protein-protein bonds. The analytical approach described provides a systematic procedure for obtaining rupture kinetics for single protein bonds from bond breakage frequency(More)
Kinetic parameters associated with bond dissociation have been identified from experiments in which mechanical forces exerted by atomic force microscopy or laser tweezers are used to break bonds in single molecules. Analysis of a single-bond microscopic model indicates that the breakage frequency distribution is most sensitive to the value of the distance(More)
A novel approach is proposed to quantify the effects of parameter uncertainties on state distributions in finite-time nonlinear distributed parameter systems, and this approach is applied to a free radical bulk polymerization reactor. For worst-case uncertainty descriptions, parameters are computed that result in worst-case deviations in the monomer(More)
Suspension polymerization is commonly used to produce micron-sized (10-1000 /spl mu/m) polymer beads, in which the final particle size distribution is an important end-use property. This paper presents an integrated approach for the modeling, simulation, and parameter estimation of particle-particle dynamics during suspension polymerization. This approach(More)
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