Learn More
To document the safety of iodixanol and to assess its pharmacokinetic properties, extensive tests have been performed. Iodixanol was rapidly excreted, mainly via the kidneys, with a plasma half-life in rats and monkeys of 25 and 76 mins, respectively. The pharmacokinetic data were consistent with an extracelleular distribution of iodixanol. During the 24(More)
The air-filled microspheres of the ultrasound-contrast agent Albunex are unique in that the walls consist of human serum albumin molecules which have been made insoluble by sonication of the albumin solution. The microspheres were isolated by flotation, and the washed microspheres were labelled with 125I. The labelled material was cleared from the(More)
In recent years there has been growing interest in discriminative parameter training techniques, resulting from notable improvements in speech recognition performance on tasks ranging in size from digit recognition to Switchboard. Typified by Maximum Mutual Information training, these methods assume a fixed statistical modeling structure, and then optimize(More)
In a wide range of preclinical studies of gadodiamide injection (Omniscan, Sanofi Winthrop, New York, NY, and Nycomed AS, Oslo, Norway), the pharmacokinetics of the compound have been delineated and its safety demonstrated. The pharmacokinetic behavior of gadodiamide was consistent with its extracellular distribution. Its half-life in rats, rabbits, and(More)
The intravenous use of roentgen contrast media (CM) is associated with a low incidence of renal impairment. This paper considers the intravascular handling and retention of CM in relation to effects on renal function - specifically the ability of the kidney to reabsorb and catabolise low molecular weight proteins. Renal morphology following experimental(More)
SUPERPARAMAGNETIC CONTRAST AGENTS FOR MAGNETIC RESONANCE IMAGING Tueng Shen Submitted to the Harvard University-Massachusetts Institute of Technology Division of Health Sciences and Technology on April 29, 1994 in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Medical Engineering/Medical Physics Abstract Magnetic resonance(More)
Dextran covalently linked to moieties of gadolinium diethylenetriamine pentaacetic acid (DTPA), for use as a macromolecular, intravascular blood pool marker for contrast material-enhanced magnetic resonance (MR) imaging was characterized by means of physicochemical and relaxivity measurements and MR imaging in healthy rats. Dextran labeled with 15 Gd-DTPA(More)
The absorption of the nonionic contrast medium iohexol, the clearance tracer 51Cr-ethylenediaminetetraacetic acid, and the blood-pool marker 125I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and 51Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and(More)
The degree of albuminuria after selective nephroangiography was investigated in anaesthetized rats. Iopentol, iopromide, iodixanol and compound 2-5410-4A all caused a slight but not statistically significant increase in albuminuria when compared with the control group. After ioxaglate injection a high degree of albuminuria was observed which was(More)