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- Edward H Flach, Vito W Rebecca, Meenhard Herlyn, Keiran S M Smalley, Alexander R A Anderson
- Molecular pharmaceutics
- 2011

The role of tumor-stromal interactions in progression is generally well accepted, but their role in initiation or treatment is less well understood. It is now generally agreed that, rather than consisting solely of malignant cells, tumors consist of a complex dynamic mixture of cancer cells, host fibroblasts, endothelial cells and immune cells that interact… (More)

- Edward H Flach, Santiago Schnell
- Mathematical biosciences
- 2010

We consider the steady state of an open biochemical pathway, with controlled flow. Previously we have shown that the steady state of open enzyme catalysed reactions may be unstable, which discourages the application of the quasi-steady-state approximation (QSSA) [IEE Proc.-Syst. Biol. 153 (2006) 187]. Here we examine basic open biochemical pathway… (More)

- P. Mutschler, E. Flach
- Conference Record of 1998 IEEE Industry…
- 1998

To achieve fast control action, direct control methods should be used. Two new types of those are presented in this paper. (1) "Direct mean torque control" (DMTC) combines the good dynamic performance of direct torque control with the advantages of inherently constant switching frequency and time equidistant control for implementation in a digital signal… (More)

- E. H. Flach, Santiago Schnell, John Norbury
- Appl. Math. Lett.
- 2007

There are two simple solutions to reaction-diffusion systems with limit-cycle reaction kinetics, producing oscillatory behaviour. The reaction parameter mu gives rise to a 'space-invariant' solution, and mu versus the ratio of the diffusion coefficients gives rise to a 'time-invariant' solution. We consider the case where both solution types may be… (More)

- Edward Flach, John Norbury, Santiago Schnell
- Biomath
- 2013

Convection-induced instability in reaction-diffusion systems produces complicated patterns of oscillations behind propagating wavefronts. We transform the system twice: into lambda-omega form, then into polar variables. We find analytical estimates for the wavefront speed which we confirm numerically. Our previous work examined a simpler system [E. H.… (More)

- Edward Flach
- 2013

We are interested in finding the kinetic parameters of a chemical reaction. Previous methods for finding these parameters rely on the dynamic behaviour of the system. This means that the methods are time-sensitive and often rely on non-linear curve fitting. In the same manner as previous techniques, we consider the concentrations of chemicals in a reaction.… (More)

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