E. H. C. Verhaeren

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Administration of 1,8-dihydroxyanthraquinone to guinea-pigs increases colonic permeability. The transfer of99mTc-labelled EDTA from mucosa to serosa was markedly increasedin vivo. In one hour 25% of the administered radioactive compound leaked out of the colon to concentrate in the urine. A similar enhanced complex transfer was observed following(More)
Administration of 1,8-dihydroxyanthraquinone (DHA) markedly increases the permeability of guinea-pig colonic mucosa. In 1 h 25% of the administered dose of 99mTc-EDTA complex leaks through the mucosa. Orally administered loperamide blocks the 99mTc-EDTA transfer after DHA administration. Loperamide injected in situ in the ligated colon segment shows the(More)
Rhein (1,8-dihydroxy-3-carboxyanthraquinone), in a concentration of 6 X 10(-4)M, inhibits water absorption from the colon and causes a net transfer of fluid and electrolyte into the intestinal lumen. Morphine (4 X 10(-4)M) counteracted the water and electrolyte secretion. Prior perfusion with morphine protected the large intestine from the laxative effect(More)
The anthranoid composition in roots of Rheum officinale has been followed during a one year cycle. No statistical correlation could be found between total anthranoid content and time of sampling. The mean total anthranoid content was found to be 3.17%, calculated on freeze dried plant material. On the other hand the ratio anthrone/total anthranoid varied(More)
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