E. Gründig

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We tested the effect of a prolonged l-DOPA therapy in 19 patients suffering from Parkinson's disease, by a) applying medical tests and b) measuring concentrations of free amino acids of cerebrospinal fluid. The period of observation ranged from 3 months up to two years, with doses from 2500 to 5000 mg l-DOPA per day. 1. In 9 patients the pattern of free(More)
The activities of the aminotransferases, GOT and GPT, were determined in the serum and cerebrospinal fluid of patients with Parkinson's disease, Huntington's chorea, Wilson's disease, amyotrophic lateral sclerosis (ALS), Friedreich's ataxia, phenylketonuria, and head injuries. 1. In patients with Huntington's chorea the activity of SGOT was lower than in(More)
1. Bei Morbus Gaucher konnte durch histochemische Testung der Gaucher-Zellen und mittels Knochenmarksbiopsie eine Verbesserung der Diagnostik erreicht werden. Besonders charakteristisch ist der Gehalt an PAS-positiven Substanzen und sauren Phosphatasen. 2. Die Aktivität der sauren Phosphatasen in Serum und Plasma steigt bis durchschnittlich 20 KAE an. Das(More)
Patients with Parkinson's disease were treated with different antiparkinsonian drugs and the amino acid levels in serum and cerebrospinal fluid were determined. Results obtained in 43 patients (L-dopa [26]; prodipine [6]; amantadine [11]) are reported. All drugs investigated produced an increase in amino acids in serum and in CSF, this enhancement being(More)