E G Caiani

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We tested the feasibility of real-time three-dimensional (3D) echocardiographic (RT3DE) imaging to measure left heart volumes at different gravity during parabolic flight and studied the effects of lower body negative pressure (LBNP) as a countermeasure. Weightlessness-related changes in cardiac function have been previously studied during spaceflights(More)
Tissue Doppler is used to evaluate mitral annulus (MA) dynamics. This technique has two major limitations: it is two-dimensional and angle-dependent. To solve these limitations, our aim was to develop and test a tool for automated 3D tracking and quantification of the MA motion throughout the cardiac cycle by using real-time 3D echocardiography (RT3DE). The(More)
Right ventricular (RV) volume quantification from cardiac magnetic resonance imaging is based on manual tracing of endocardial boundaries and application of geometric modeling. This procedure is subjective, time-consuming and may bias volume measurements since the right ventricle is a complex structure that is not well suited to a geometric model. We(More)
OBJECTIVE To develop a technique for volumetric analysis of real time three dimensional echocardiography (RT3DE) data aimed at quantifying left ventricular (LV) mass and to validate the technique against magnetic resonance (MR) assumed as the reference standard. DESIGN RT3DE, which has recently become widely available, provides dynamic pyramidal data(More)
Parabolic flight (PF) elicits changes in hydrostatic pressure gradients, resulting in increase (at 0Gz) or decrease (at 1.8Gz) in cardiac preload. The magnitude of these changes on left ventricular (LV) and atrial (LA) volumes, as well as on myocardial velocities, strain and strain rates, is largely unknown. Using real-time 3D (RT3DE) and Doppler tissue(More)
The recently developed echocardiographic matrix array transesophageal (mTEE) transducer provides real-time 3D images of high spatial and temporal resolution that may be suitable for detailed simultaneous study of functional anatomy of the mitral and aortic valves. We developed software that detects and tracks throughout the cardiac cycle mitral and aortic(More)
Cardiac magnetic resonance imaging (CMRI) is the standard for estimates of LV volumes, ejection fraction and mass. These computations are based on extensive manual tracing of endocardial and epicardial borders and are subjective and time-consuming. We developed a new technique for semi-automated surface detection for the measurement of LV end-systolic and(More)
Although abnormal motion of the interventricular septum (IVS) caused by elevated right ventricular pressure in patients with pulmonary hypertension (PH) is easy to recognize visually, determination of the severity of PH relies on measurements of pulmonary arterial pressure (PAP). We hypothesized that quantitative 3D analysis of regional IVS curvature(More)
Dynamic, ECG-gated, steady-state free precession short-axis images were obtained (GE Healthcare, 1.5T) in 8–12 slices in 15 patients with previous myocardial infarction. An expert cardiologist provided the reference values for: 1) left ventricular (LV) volumes and mass, by manually tracing endo and epicardial contours; 2) regional wall motion (WM)(More)
Mitral valve (MV) repair is the preferential treatment for mitral regurgitation (MR) associated with degenerative MV disease, and the functional benefits of early surgery are known. Our goal was to evaluate the changes in LV shape following MV repair, using a new method based on real-time 3D echocardiography (RT3DE). Fifty patients with severe asymptomatic(More)