E. G. Bogdanov

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alpha 2-Agonist clonidine has been used for several years in the detoxification of opiate-addicts since it reduces withdrawal symptoms in man although craving for narcotic is not well suppressed. In the present work the potential "anticraving" properties of another alpha 2-agonist guanfacine were studied in rats trained to self-administer morphine. In the(More)
It has been demonstrated in experiments on nonanesthetized intact and spinalized cats that intrathecal morphine increased blood pressure and renal nerve sympathetic activity and enhanced the nociceptive reactions. It is suggested that morphine plays an essential role in the effect of propriospinal system on the generation of sympathetic spinal reflexes.
Experimental and clinical observations have shown that opiates and ophoids, in analgesic doses, do not change nociceptive hemodynamic reactions or potentiate them. One of the mechanisms of the pharmacologic resistance of circulatory changes during pain is the activating effect of morphinelike analgesics on the propriospinal system for generalization of(More)
The basic essentials of research in neurophysiology are the fullest possible analysis of the electrical activity of nerve structures and discovery of their functional importance. Existing methods and equipment for automated data analysis (systems of ATAS, AI Neiron type, and the like) increase the objectivity of measurement and integrate values of spike(More)
together with its physiologically manifested B-stimulating activity. As was noted previously [i], this mechanism of self-limitation of its own sympathomimetic activity may perhaps play a role in the realization of some positive properties of nonachlazine and, in particular, its ability to potentiate the inotropic function of the heart without the(More)
In experiments on conscious and unanesthetized cats it was shown that clopheline in analgesic doses do not change the pain baroreflex blood pressure regulation and mild brain antinociceptive sympathoactivating influences. The clopheline antihypertensive effect was due to nonopiate direct sympathoinhibitory effect realized by suprasegmental level of(More)