E F Sarkisova

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The morpho-functional development of the visual area of the cerebral cortex of newborn rats and effects of serotonin (5-HT) on these processes were studied in long-term (up to 40 days) organotypic cultures. It was shown that systematic addition of 5-HT in physiological concentrations to the nutrient medium during cultivation of the explants stimulates glia(More)
It has been demonstrated in combined (raphé nuclei-hippocampus, cerebellum-hippocampus) organotypical cultures of the brain of newborn rats that, unlike cerebellar explants, the raphé nuclei grow in an oriented manner toward the hippocampus and exert a stimulating influence on its morphofunctional development; this is manifested: a) in an intense(More)
During cocultivation in vitro, raphe nuclei, as distinct from cerebellum, were shown to stimulate the growth and morphofunctional development of hippocampus, including glia proliferation, neurite outgrowth, earlier formation of spontaneous unit activity, greater number of active neurons, and predominance of cells with a periodic type of activity. These(More)
The paper deals with morpho-functional development of the visual area of newborn rats cerebral cortex in conditions of prolonged (up to 40 days) organotypical cultivation and with the effect of serotonin (5-OT) on these processes. It has been shown that systematic addition of physiological concentrations of 5-OT to the nutrient medium during explantates(More)
Morpho-functional development of the raphe nuclei neurons was studied in long-term (up to 20 days) organotypic cultures taken from newborn rats. Differentiated neurons typical for raphe nuclei were identified in explants after 10 days in vitro. The synthesis of serotonin (5-HT) and uptake of 3H-5-HT were more intense in the raphe neurons culture than in(More)
The influence of noradrenaline (NA) on the functional development and chemical sensitivity of neurons of the newborn rat hippocamp was studied in organotypic cultures during the period of up to 38 days. NA was shown to inhibit the formation of spontaneous activity and lessen the number of active neurons in the explants. In these cultures, like in hippocamp(More)
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