E E Mirskaia

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Extracts from bottom sediments sampled in the Bering Sea and in certain regions of the Pacific Ocean were studied. Benzene and acetone-hexane extracts were tested for mutagenicity by Ames' bacterial test-system using the TA 98 and TA 100 Salmonella typhimurium strains. Extract from 4 stations of the 10 studied ones produced significant increase in the(More)
Changes in the mutagenic activity of the nutrient medium containing aflatoxin Br as a result of living activity of the yeast Rhodotorula mucilaginosa I B has been studied. Reduction of mutagenic activity of the medium when tested on the strains Salmonella typhimurium TA98 (6.3 times fold), TA100 (2.2 times fold), AG262 (2 times fold) has been revealed. The(More)
The murine bone marrow cellular chromosomal aberration technique was used to reveal anticlastogenic effects of the natural interferon inductors ridostin and larifan, as well as the synthetic ones polyguacil and amyxin. The action of the interferon inductors was timed to the maximum production of interferon in the body. Anticarcinogenic, antitumor, and(More)
Comparative analysis of UV induction of tandem chromosome (Mtc+) duplications and reversions of point mutations (base pair substitutions) and of insertion mutations (precise excision of Tn10) was carried out. Salmonella (umuST) genes deficiency preventing dose-dependent UV induction of point mutation reversion were shown to have a less pronounced effect on(More)
A pair of isogenic strains-E. coli K-12 and E. coli B/r differing by the status of umuDC genes and presence of pKM101 plasmid-were constructed and the relationship between UV induction of transposons Tn5 and Tn 10 and the gene umuDC function shown. This relationship is not absolute, in contrast to that of point mutations. Induction of precise excision of(More)
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