E. E. Grishina

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An increased level of mutagenesis, partially caused by imbalanced activities of error prone DNA polymerases, is a key symptom of cell malignancy. To clarify the possible role of incorrect DNA polymerase iota (Pol iota) function in increased frequency of mutations in mammalian cells, the activity of this enzyme in extracts of cells of different mouse organs(More)
DNA polymerase iota (Pol ι) which has some peculiar features and is characterized by an extremely error prone DNA synthesis, belongs to the group of enzymes preferentially activated by Mn2+ instead of Mg2+. In this work, using misGvA method (misincorporation of “G” versus “A”, method of Gening) we studied the effect of Mn2+ on DNA synthesis in cell extracts(More)
The results are available of clinical, morphological, cytological and immunological investigations of orbital lymphomas and lymphomas of appendages of the eye. Malignant lymphoma was detected in 17 patients and reactive lymphoid hyperplasia in 3 patients. All the malignant lymphomas had B-cell phenotype. By cell composition, MALT-lymphoma is more(More)
Methods of diagnostics of primary intraocular lymphomas associated with primary CNS lymphomas are described. This article demonstrates the value of neurophtalmological assessment before surgery in patients with intracranial space occupying lesions. Three cases with bilateral primary intraocular lymphomas are presented. Authors analyzed initial results of(More)
Based of their experience and analysis of the papers available in the medical literature, the authors describe the clinical picture of malignant lymphomas of the organ of vision. They give a concept of the current classification of lymphomas and information on the specific features of their course, by taking into account the site of the process (eyelids,(More)
The authors analyse the results of echobiometry carried out in 21 patients with choroid nevi and in 8 patients with primary melanomas of the choroid, administered no treatment for this or that reason. Nevi with a prominence of less than 1 mm were found to be the most incident, and their elevation did not increase over the course of the follow-up. Only in(More)
Clinical symptoms in patients with primary orbital lymphosarcoma, generalized lymphosarcoma involving the orbital tissues, and metastatic tumors of the orbit of another origin are analyzed. The orbital process has bee studied in 158 patients. The most frequent symptoms were ptosis and exophthalmos. Decreased visual acuity, pain, sensation of swelling in the(More)
Enzymatic activity of DNA polymerase iota (Pol t) was analyzed in human uveal melanoma cell extracts, using an earlier elaborated approach. The Pol t activity was observed in seven out of eight malignant tumors, while it was absent in the normal uveal tract cells of the same patients. These findings serve as an additional confirmation of the Pol t oncogenic(More)
The article presents a rare clinical case of intraocular schwannoma localized in the pre-equatorial choroidea and the pars plana and complicated by secondary glaucoma. Prolonged course of the disease and the presence of scleral staphyloma allowed to assume benign nature of the tumor. Enucleation was performed due to painful secondary glaucoma. Histological(More)
2 cases of sinus histiocytosis with massive lymphadenopathy are reported. The disease belongs to non-neoplastic lesions associated with proliferation of histiocytes with antigen-treating function. A case of sarcoma is also described. It consisted of follicular dendritic cells related to histiocytes with the antigen-representing function.