E Donsez-Darcel

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The murine steroid sulfatase (mSTS) is a microsomal enzyme, important in steroid metabolism. In the mouse, the gene encoding mSTS is pseudoautosomal and thus escapes X-inactivation. We have purified steroid sulfatase approximately 30-fold from mouse liver microsomes and its properties have been investigated. The major steps in the purification procedure(More)
The microsomal enzyme steroid sulfatase (STS, E.C. plays a central function in the neurosteroid mode of action, since it is responsible for the switch between the sulfated and the free forms of steroids which have opposite effects. In this study, using an enzyme linked immunosorbent assay (ELISA) for the STS, we have investigated the brain(More)
The pairing region of the X-Y chromosomes recombines at male meiosis. We previously found that offense behavior in male mice, measured by initiation of attack against a conspecific male, was linked to this region. Only one functional gene (coding for steroid sulfatase or Sts) is mapped on this region as of yet, suggesting that it could be a candidate for(More)
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