E Danese

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BACKGROUND Tumour-released DNA in blood represents a promising biomarker for cancer detection. Although epigenetic alterations such as aberrant promoter methylation represent an appealing perspective, the discordance existing between frequencies of alterations found in DNA extracted from tumour tissue and cell-free DNA (cfDNA) has challenged their practical(More)
Sir, Huhtinen et al (2009) recently reported about the usefulness of Human Epididymal Protein 4 (HE4) in discriminating ovarian tumours from ovarian endometriotic cysts, which is of pivotal importance as CA125 is often increased in benign gynaecological diseases such as endometriosis (Muyldermans et al, 1995). Therefore, we performed a similar study on 46(More)
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