E. D. Miskarova

Learn More
The acute febrile disease with characteristic rash seen in Astrakhan region and named as “viral exanthema of unknown etiology” was proved to be a spotted fever group rickettsiosis. Serological examination of humans from endemic areas by complement fixation test revealed antibodies to R. conorii, R. akari and strains Netsvetaev and AR-74 of R. sibirica in(More)
Cytological and cytochemical studies on Swiss and random-bred white mice susceptible to Rickettsia tsutsugamushi infection as well as resistant C57 Black 6 and CBA mice revealed a clear-cut relationship between the severity of infection and the pattern of macrophage reaction. In highly susceptible mice the fatal infection was accompanied by death of(More)
Microcinematography, cytological and cytochemical studies revealed new features of D. sibericus, D. murinus, and R. tsutsugamushi biology, mainly a very active movement in the cell. In contrast to D. sibericus, development of D. murinus and R. tsutsugamushi in cells is characterized by severe irritation of the infected cells early in the infection, a(More)
Delayed type hypersensitivity (DTH) was studied in the macrophage migration inhibition test, antibody titers in the CFT and functional activity of spleen macrophages, obtained from guinea-pigs infected with R. conori, in cell cultures. No direct correlation between antibody synthesis and functional macrophage activity accompanied by the development of DTH(More)
Antibody production has been studied in cotton B-rats and in CBA B-mice during immunization with chemical typhus vaccine (CTV) and during infection with Rickettsia prowazekii. Studies of the immune response to rickettsial antigen in T-deficient animals have shown a high immunogenicity of CTV and independence of antibody production on T-lymphocytes. Active(More)