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This article presents an end-to-end reservation protocol for Quality of Service (QoS) support in the MAC layer of wireless multihop mesh networks. It reserves periodically repeating time slots for QoS-demanding applications, while retaining the Distributed Coordination Function (DCF) for besteffort applications. The key features of the new protocol, called(More)
This paper examines a new mechanism for distributed resource reservation that offers support for applications with QoS requirements in a wireless multi-hop network. This mechanism is based on IEEE 802.11 DCF and includes end-to-end reservations of time slots and distribution of reservation information to mobile nodes unaware of the reservation, piggy-backed(More)
Extensive screening of compound libraries was undertaken to identify compounds with high affinity for the rat NK(1) receptor based on inhibition of [(125)I]-substance P binding. RP67580, SR140333, NKP-608 and GR205171 were selected as compounds of interest, with cloned rat NK(1) receptor binding K(i) values of 0.15-1.9 nM. Despite their high binding(More)
DNA from Chlamydia trachomatis serovars L3, C, and E corresponding to the open reading frames of the 60-kDa protein and of a putative 15-kDa protein was sequenced. The open reading frames coding for the 60-kDa protein had 1,641 bp in the three serovars. Compared with the L3 serovar, there were 9 and 11 amino acid changes in the C and E serovars,(More)
Neutralization of the infectivity of Chlamydia trachomatis was assessed by using polyclonal antisera and monoclonal antibodies (MAbs). Polyclonal antisera and a species-reactive MAb as well as a subspecies-specific MAb, both of which were directed toward the major outer membrane protein of C. trachomatis, reduced the number of chlamydial inclusion-forming(More)
The preparation and structure-activity-relationships of novel pyrrolidine-carboxamides and oxadiazoles are described. Compounds in this series were found to be potent hNK(1) antagonists in vitro and efficacious in vivo with minimal interactions with P(450) liver enzymes. Oxadiazole analog 22 was determined to have excellent hNK(1) binding affinity,(More)
Supporting applications with high quality-of-service requirements in wireless multihop networks is challenging, mainly due to uncertainties about the packet forwarding times introduced by the data link layer at every node on the path to the destination. For instance, networks based on IEEE 802.11 exhibit such variable forwarding times due to their CSMA(More)
We compare two approaches for Quality of Service support in WLAN-based ad hoc networks. The first approach is to use per-packet priorities, according to the IEEE 802.11e standard. The second approach is to allocate radio resources on the path between source and destination, according to our protocol ’Distributed end-to-end Allocation of time slots for(More)
3-[(3aR,4R,5S,7aS)-5-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-4-(4-fluorophenyl)octahydro-2H-isoindol-2-yl]cyclopent-2-en-1-one (17) is a high affinity, brain-penetrant, hydroisoindoline-based neurokinin-1 (NK(1)) receptor antagonist with a long central duration of action in preclinical species and a minimal drug-drug interaction profile. Positron(More)